N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes.
(+)-Isolariciresinol monoglucoside ((+)-Isolariciresinol 9'-O-glucoside) is a lignan glycoside isolated from several plants[1][2].
NFQ1 is a non-fluorescent quencher (absorption wavelength: 474 nm), and is used for a new type of One Sample Fluorescence Resonance Energy Transfer (OS-FRET) method. OS-FRET enable measurement of unquenched donor emission in the same sample. NFQ1 shows broad absorption spectrum ensuring its utility as a dark acceptor for many donors[1].
Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820)[1]. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects[2].
Alpha-d-Glucopyranoside, beta-d-fructofuranosyl, octadecanoate is a carbohydrate.
(2S)-4-(benzyloxy)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-oxobutanoic acid is an aspartic acid derivative[1].
RXFP3/4 agonist 2 is a potent, nonpeptide dual RXFP3/4 agonist (EC50=3.1 and 2.7 nM). RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC50 values in the range of 10-22 nM[1].
6-O-Nicotinoylscutebarbatine G is an alkaloid that can be isolated from Scutellaria barbata.6-O-Nicotinoylscutebarbatine has cytotoxic activities against HONE-1, KB and HT29 cells with IC50s of 3.1, 2.1 and 5.7 μM, respectively[1].
Dihydropalmatine is a alkaloid isolated from Berberis aristata[1].
D-N-(Benzyloxycarbonyl)leucine is a leucine derivative[1].
Cycloeucalenol is a triterpenoid compound derived from Eucalyptus microcorys[1].
Scutellarin methyl ester is a constituent of Breviscapine which is a crude extract of several flavonoids of Erigeron breviscapus[1][2].
Vinaginsenoside R3 is a saponin composition of roots of Panax ginseng. Ginsengs have been not only used as therapeutic agents with tonic, sedative, anti-fatigue, and anti-gastric ulcer effect but also marketed as dietary supplements and raw materials of health food[1].
Anhydroglycinol is a phenolic compound that can be isolated from Lespedeza homoloba. Anhydroglycinol has strong antioxidative and antiallergic activity against lipid peroxidation in the rat[1].
Arjunglucoside II is a triterpenes that can be isolated from Terminalia fagifolia[1].
4-Carboethoxypiperidine-d9 is the deuterium labeled 4-Carboethoxypiperidine[1].
1-Phenylbutan-1-one-d5 is the deuterium labeled 1-Phenylbutan-1-one[1].
2-((tert-Butoxycarbonyl)amino)-2-cyclohexylacetic acid is a Glycine (HY-Y0966) derivative[1].
16-Acetoxy-7-O-acetylhorminone is a compound isolated from the leaves of Rabdosia lophanthoides var. gerardiana[1].
4-(3, 4-dihydroxyphenyl)butan-2-one is a compound isolated from the subspecies Lactobacillus plantarum subsp. argentoratensis. 4-(3, 4-dihydroxyphenyl)butan-2-one has antioxidant and anti-inflammatory activity. 4-(3, 4-dihydroxyphenyl)butan-2-one can be used for research of microbial fermentation [1].
Swertiaside is a natural product, that can be isolated from Swertia mussotii Franch[1].
LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles[1].
Macrocarpal J, a phloroglucinol?sesquiterpene-coupled compound, can be isolated from the leaves of Eucalyptus globulus[1].
KTX-582 intermediate-2 is an intermediate in the synthesis of KTX-582 (HY-148274) and can be used for ADC preparation. KTX-582 is an IRAK4 degrader and inducer of apoptosis with DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively[1].
Albiflorin is a major constituent contained in peony root; possesses therapeutic potential for neurodegenerative diseases.IC50 value:Target: in vitro: Albiflorin significantly ameliorated Glu-induced reduction of cell viability, nuclear and mitochondrial apoptotic alteration, reactive oxygen species accumulation, and B-cell lymphoma 2 (Bcl-2)/Bax ratio. Albiflorin also enhanced phosphorylation of AKT and its downstream element glycogen synthase kinase-3β, and this effect was abrogated by the AKT inhibitor LY294002 [1]. in vivo: Mice were exposed to X-ray radiation (400 Roentgen), and both mice and rabbits were intraperitoneally injected with cyclophosphamide (100.0 mg/kg) and cytarabine chloride (92.7 mg/kg), respectively, for 3 days to induce myelosuppression. Albiflorin was subsequently administrated intravenously at low (15.0 mg/kg for mice, 6.00 mg/kg for rabbits), intermediate (30.0 mg/kg for mice, 12.0 mg/kg for rabbits) and high (60.0 mg/kg for mice, 24.0 mg/kg for rabbits) doses, as well as orally (60.0 mg/kg for mice, 24.0 mg/kg for rabbits) for 7 days. Shenqi tablets were used as positive controls (oral administration of 936.0 mg/kg for mice, 336.0 mg/kg for rabbits). The administration of Albiflorin significantly ameliorated myelosuppression in all cases [2].
Hepln-13 is a potent and orally active Hepsin inhibitor with an IC50 of 0.33 µM. Hepln-13 can be used for the research of metastatic prostate cancer[1].
Cbz-D-Valine is a valine derivative[1].
NIR-641 N-succinimidyl ester is a fluorescent dye[1].
N-[(1,1-Dimethylethoxy)carbonyl]-1-(triphenylmethyl)-D-histidine is a histidine derivative[1].
Astragaloside III is a natural product isolated from Astragalus.