Chemsrc provides Others's classification. They are divided into Androgen Receptor, Aromatase, Estrogen Receptor/ERR, Progesterone Receptor, Thyroid Hormone Receptor, Others according to their Biological activity.


Anti-infection >
Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HIV HSV Influenza Virus Parasite Reverse Transcriptase RSV SARS-CoV
Antibody-drug Conjugate >
ADC Cytotoxin ADC Linker Drug-Linker Conjugates for ADC PROTAC-linker Conjugate for PAC
Apoptosis >
Apoptosis Bcl-2 Family c-Myc Caspase DAPK Ferroptosis IAP MDM-2/p53 PKD RIP kinase Survivin Thymidylate Synthase TNF Receptor
Autophagy >
Autophagy LRRK2 ULK Mitophagy
Cell Cycle/DNA Damage >
Antifolate APC ATM/ATR Aurora Kinase Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA-PK DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF) G-quadruplex Haspin Kinase HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 Nucleoside Antimetabolite/Analog p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 ROCK Sirtuin SRPK Telomerase TOPK Topoisomerase Wee1
Cytoskeleton >
Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK
Epigenetics >
AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MicroRNA PARP PKC Sirtuin Protein Arginine Deiminase
GPCR/G Protein >
5-HT Receptor Adenosine Receptor Adenylate Cyclase Adiponectin Receptor Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR Dopamine Receptor EBI2/GPR183 Endothelin Receptor GHSR Glucagon Receptor Glucocorticoid Receptor GNRH Receptor GPCR19 GPR109A GPR119 GPR120 GPR139 GPR40 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR MCHR1 (GPR24) Melatonin Receptor mGluR Motilin Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor Prostaglandin Receptor Protease-Activated Receptor (PAR) Ras RGS Protein Sigma Receptor Somatostatin Receptor TSH Receptor Urotensin Receptor Vasopressin Receptor Melanocortin Receptor
Immunology/Inflammation >
Aryl Hydrocarbon Receptor CCR Complement System COX CXCR FLAP Histamine Receptor IFNAR Interleukin Related IRAK MyD88 NO Synthase NOD-like Receptor (NLR) PD-1/PD-L1 PGE synthase Salt-inducible Kinase (SIK) SPHK STING Thrombopoietin Receptor Toll-like Receptor (TLR) Arginase
JAK/STAT Signaling >
EGFR JAK Pim STAT
MAPK/ERK Pathway >
ERK JNK KLF MAP3K MAP4K MAPKAPK2 (MK2) MEK Mixed Lineage Kinase MNK p38 MAPK Raf Ribosomal S6 Kinase (RSK)
Membrane Transporter/Ion Channel >
ATP Synthase BCRP Calcium Channel CFTR Chloride Channel CRAC Channel CRM1 EAAT2 GABA Receptor GlyT HCN Channel iGluR Monoamine Transporter Monocarboxylate Transporter Na+/Ca2+ Exchanger Na+/HCO3- Cotransporter Na+/K+ ATPase nAChR NKCC P-glycoprotein P2X Receptor Potassium Channel Proton Pump SGLT Sodium Channel TRP Channel URAT1
Metabolic Enzyme/Protease >
15-PGDH 5 alpha Reductase 5-Lipoxygenase Acetyl-CoA Carboxylase Acyltransferase Adenosine Deaminase Adenosine Kinase Aldehyde Dehydrogenase (ALDH) Aldose Reductase Aminopeptidase Angiotensin-converting Enzyme (ACE) ATGL ATP Citrate Lyase Carbonic Anhydrase Carboxypeptidase Cathepsin CETP COMT Cytochrome P450 Dipeptidyl Peptidase Dopamine β-hydroxylase E1/E2/E3 Enzyme Elastase Enolase FAAH FABP Factor Xa Farnesyl Transferase Fatty Acid Synthase (FAS) FXR Glucokinase GSNOR Gutathione S-transferase HCV Protease Hexokinase HIF/HIF Prolyl-Hydroxylase HIV Integrase HIV Protease HMG-CoA Reductase (HMGCR) HSP Indoleamine 2,3-Dioxygenase (IDO) Isocitrate Dehydrogenase (IDH) Lactate Dehydrogenase LXR MAGL Mineralocorticoid Receptor Mitochondrial Metabolism MMP Nampt NEDD8-activating Enzyme Neprilysin PAI-1 PDHK PGC-1α Phosphatase Phosphodiesterase (PDE) Phospholipase Procollagen C Proteinase Proteasome Pyruvate Kinase RAR/RXR Renin ROR Ser/Thr Protease SGK Stearoyl-CoA Desaturase (SCD) Thrombin Tryptophan Hydroxylase Tyrosinase Xanthine Oxidase
Neuronal Signaling >
5-HT Receptor AChE Adenosine Kinase Amyloid-β Beta-secretase CaMK CGRP Receptor COMT Dopamine Receptor Dopamine Transporter FAAH GABA Receptor GlyT iGluR Imidazoline Receptor mAChR Melatonin Receptor Monoamine Oxidase nAChR Neurokinin Receptor Opioid Receptor Serotonin Transporter γ-secretase
NF-κB >
NF-κB IKK Keap1-Nrf2 MALT1
PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
Ack1 ALK Bcr-Abl BMX Kinase Btk c-Fms c-Kit c-Met/HGFR Discoidin Domain Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 IGF-1R Insulin Receptor IRAK Itk PDGFR PKA Pyk2 ROS Src Syk TAM Receptor Trk Receptor VEGFR
Stem Cell/Wnt >
Casein Kinase ERK Gli GSK-3 Hedgehog Hippo (MST) JAK Notch Oct3/4 PKA Porcupine ROCK sFRP-1 Smo STAT TGF-beta/Smad Wnt YAP β-catenin γ-secretase
TGF-beta/Smad >
TGF-beta/Smad PKC ROCK TGF-β Receptor
Vitamin D Related >
VD/VDR
Others >
Androgen Receptor Aromatase Estrogen Receptor/ERR Progesterone Receptor Thyroid Hormone Receptor Others

γ-Linolenic acid

Gamma-linolenic acid is an omega-6 (n-6), 18 carbon (18C-) polyunsaturated fatty acid (PUFA) extracted from human milk and several botanical seed oils. Gamma-linolenic acid supplements could restore needed PUFAs and mitigate the disease[1].

  • CAS Number: 506-26-3
  • MF: C18H30O2
  • MW: 278.430
  • Catalog: Others
  • Density: 0.9±0.1 g/cm3
  • Boiling Point: 379.5±11.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 276.4±14.4 °C

(Ser4,Ile8)-Oxytocin

Isotocin ((Ser4,Ile8)-Oxytocin) is a biologically active peptide.

  • CAS Number: 550-21-0
  • MF: C41H63N11O12S2
  • MW: 966.13500
  • Catalog: Others
  • Density: 1.277 g/cm3
  • Boiling Point: 1483.4ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 850.9ºC

Cinnamtannin B2

Cinnamtannin B2 (compound 12) is a cinnamon tannin isolated from Vaccinium vitis-idaea L[1].

  • CAS Number: 88038-12-4
  • MF: C60H48O24
  • MW: 1153.01000
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Malabaricone C

Malabaricone C is a natural sphingomyelin synthase (SMS) inhibitor with IC50s of 3 and 1.5 μM for SMS 1 and 2, respectively[1].

  • CAS Number: 63335-25-1
  • MF: C21H26O5
  • MW: 358.42800
  • Catalog: Metabolic Disease
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

bryonamide B

Bryonamide B is a Cucurbitane-Type triterpenoid isolated from Bryonia aspera[1].

  • CAS Number: 5942-25-6
  • MF: C10H13NO4
  • MW: 211.21500
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Talsupram hydrochloride

Talsupram (hydrochloride) is a selective norepinephrine inhibitor with high affinity for norepinephrine transporter (NET) and can be used in the study of neuropathic pain[1].

  • CAS Number: 25487-28-9
  • MF: C20H26ClNS
  • MW: 347.95
  • Catalog: Neurological Disease
  • Density: 1.043g/cm3
  • Boiling Point: 427.6ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 212.4ºC

Fmoc-N-Me-Thr(Bzl)-OH

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-benzyl-N-methyl-L-threonine is a threonine derivative[1].

  • CAS Number: 198561-81-8
  • MF: C27H27NO5
  • MW: 445.507
  • Catalog: Others
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 622.0±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 330.0±31.5 °C

(R)-Vitamin D2

(R)-Vitamin D2 is the inactive isomer of Vitamin D2 (HY-76542), and can be used as an experimental control. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D[1][2].

  • CAS Number: 116559-84-3
  • MF: C28H44O
  • MW: 396.65
  • Catalog: Cancer
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

1-[(methylcarbamoyl)amino]-1-oxopropan-2-yl4-{[(4-methyl-2-oxo-2h-chromen-7-yl)oxy]methyl}benzoate

MuRF1-IN-2 (Example 3) is a MuRF1 inhibitor. MuRF1-IN-2 can be used for research of muscle wasting conditions, of skeletal or cardial muscle atrophy[1].

  • CAS Number: 937891-74-2
  • MF: C23H22N2O7
  • MW: 438.43
  • Catalog: Inflammation/Immunology
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Docosahexaenoic Acid methyl ester

Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.

  • CAS Number: 2566-90-7
  • MF: C23H34O2
  • MW: 342.515
  • Catalog: Neurological Disease
  • Density: 0.9±0.1 g/cm3
  • Boiling Point: 429.9±24.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 103.9±21.2 °C

N-(3-Aminopropyl)glycine Dihydrochloride

N-(3-Aminopropyl)glycine Dihydrochloride is a Glycine (HY-Y0966) derivative[1].

  • CAS Number: 90495-95-7
  • MF: C5H13ClN2O2
  • MW: 168.62200
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Acyl Carrier Protein (ACP) (65-74) (acid)

Acyl Carrier Protein (ACP) (65-74) is an active acyl carrier protein (ACP) fragment[1].

  • CAS Number: 66851-75-0
  • MF: C47H74N12O16
  • MW: 1063.16
  • Catalog: Others
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 1574.4±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 906.0±34.3 °C

N-(4-aminobenzoyl)-L-glutamic acid

(4-Aminobenzoyl)-L-glutamic acid is a glutamic acid derivative[1].

  • CAS Number: 4271-30-1
  • MF: C12H14N2O5
  • MW: 266.250
  • Catalog: Others
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 607.1±55.0 °C at 760 mmHg
  • Melting Point: ~175 °C (dec.)
  • Flash Point: 321.0±31.5 °C

p-Azoxyanisole-d6

p-Azoxyanisole-d6 is the deuterium labeled p-Azoxyanisole[1].

  • CAS Number: 34172-21-9
  • MF: C14H8D6N2O3
  • MW: 264.31000
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

RuBi-GABA

RuBi-GABA is a new ruthenium-based caged GABA compound. RuBi-GABA photocleaves and releases GABA after being excited with visible wavelengths. RuBi-GABA produces gaba receptor-mediated currents[1].

  • CAS Number: 1028141-88-9
  • MF: C42H39Cl6N5O2P2Ru
  • MW: 1021.527
  • Catalog: Neurological Disease
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

(S,R,S)-AHPC-C6-PEG3-butyl-N3

(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S,R,S)-AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate[1].

  • CAS Number: 2300155-90-0
  • MF: C38H59N7O7S
  • MW: 757.983
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Insulin alpha-chain 1-13

Insulin alpha-chain (1-13) is a human leucocyte antigen (HLA)-DR4-restricted epitope comprising the first 13 amino acids of the insulin A-chain[1].

  • CAS Number: 872036-64-1
  • MF: C66H118N20O22S3
  • MW: 1639.96
  • Catalog: Metabolic Disease
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

carpalasionin

Carpalasionin is a natural product derived from Rabdosia serra. Rabdosia serra is an important component of Chinese herbal teas, traditionally used to treat hepatitis, jaundice, cholecystitis and colitis[1].

  • CAS Number: 83150-97-4
  • MF: C22H28O8
  • MW: 420.453
  • Catalog: Others
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 655.9±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 229.9±25.0 °C

GBT-440

GBT 440 (Voxelotor) is an orally bioavailable modulator of sickle cell hemoglobin.

  • CAS Number: 1446321-46-5
  • MF: C19H19N3O3
  • MW: 337.372
  • Catalog: Cardiovascular Disease
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 539.2±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 279.9±30.1 °C

Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH

Abz-GIVRAK(Dnp) is the most efficient substrate for cathepsin B and is highly selective for this enzyme among lysosomal cysteine proteases. After Abz-GIVRAK(Dnp) is hydrolyzed, aminoacylbenziminosulfosuccinic acid (Abz-SAS) is released, and dinitrobenzoyl (Dnp) is also released. The product of this hydrolysis reaction, Abz-SAS, is fluorescent under ultraviolet light and can emit a fluorescent signal[1].

  • CAS Number: 827044-38-2
  • MF: C41H61N13O12
  • MW: 928.00
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Parvisoflavanone

Parvisoflavanone is an isoflavanone that can be isolated from Mucuna pruriens[1].

  • CAS Number: 49776-79-6
  • MF: C17H16O7
  • MW: 332.30
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Hirsutal 5-O-glucoside

Hirsutanonol 5-O-glucoside is a diarylheptanoid derivatives that can be isolated from Alnus hirsuta. Hirsutanonol 5-O-glucoside exhibits significant hepatoprotective effects against t-BHP-induced toxicity in HepG2 cells with 42.8% protection[1].

  • CAS Number: 93915-36-7
  • MF: C25H32O11
  • MW: 508.515
  • Catalog: Cancer
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 867.0±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 292.3±27.8 °C

Fmoc-N-Me-<SC>D</SC>-Ala-OH

Fmoc-N-Me-D-Ala-OH is an alanine derivative[1].

  • CAS Number: 138774-92-2
  • MF: C19H19NO4
  • MW: 325.358
  • Catalog: Others
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 514.9±29.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 265.2±24.3 °C

Cdc2 kinase substrate

Cdc2 kinase substrate is a biological active peptide. (The native peptide HATPPKKKRK is a substrate for cyclin-dependent protein kinase 1 (CDC2; CDK1).)

  • CAS Number: 956004-38-9
  • MF: C53H95N19O12
  • MW: 1190.44
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

3,29-O-dibenzoyloxykarounidiol

3,29-O-Dibenzoyloxykarounidiol (Karounidiol dibenzoate) is a triterpene benzoate isolated from the fruit of Momordica grosvenori. 3,29-O-Dibenzoyloxykarounidiol has potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by by 12-O-tetradecanoylphorbol-13-acetate (TPA)[1].

  • CAS Number: 389122-01-4
  • MF: C44H56O4
  • MW: 648.91
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

HIV-1 gag Protein p24 (194-210)

HIV-1 gag Protein p24 (194-210) is a biologically active peptide.

  • CAS Number: 141281-67-6
  • MF: C73H126N20O23S
  • MW: 1683.967
  • Catalog: Others
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 1934.7±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 1123.9±34.3 °C

(R)-SCH 42495

(R)-SCH 42495 is the less active enantiomer of SCH 42495[1]. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester prodrug of SCH 42354[2].

  • CAS Number: 156792-25-5
  • MF: C20H29NO4S2
  • MW: 411.58
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

LONAZOLAC CALCIUM SALT

Lonazolac (hemicalcium) is the calcium salt form of Lonazolac. Lonazolac is a nonsteroidal antirheumatic agent with anti-inflammatory properties[1].

  • CAS Number: 75821-71-5
  • MF: C34H24CaCl2N4O4
  • MW: 663.56300
  • Catalog: Inflammation/Immunology
  • Density: N/A
  • Boiling Point: 525.1ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 271.4ºC

Tetramethyl-ammonium Bromide-d12

Tetramethyl-ammonium Bromide-d12 is the deuterium labeled TMAB[1].

  • CAS Number: 284474-82-4
  • MF: C4BrD12N
  • MW: 166.12300
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: >300ºC
  • Flash Point: N/A

Kobusone

Kobusoneis a natural compound isolated form Aquilaria sinensis. kobusone can stimulate islet β-cellreplication in vivo, and has the potential to be used in diabeticstudy[1][2].

  • CAS Number: 24173-71-5
  • MF: C14H22O2
  • MW: 222.323
  • Catalog: Metabolic Disease
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 308.0±25.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 123.8±16.7 °C