A potent and selective, CNS penetrant mGlu2 negative allosteric modulator with IC50 of 78 nM; shows no inhibition for mGlu3 (IC50>30 uM); represents an exciting lead series for potential mGlu2 PET tracer development.
Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model[1][2].
6α-Hydroxypolyporenic acid C, a lanostane triterpenoid, is a nature product that could be isolated from the sclerotium of Poria cocos. 6α-Hydroxypolyporenic acid C can be absorbed across intestinal epithelial cells[1].
Galactose 1-phosphate is an intermediate in the galactose metabolism and nucleotide sugars.
Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2[1].
Dihydroconiferyl alcohol is a cell division factor that can be found in pring sap of Acer pseudoplatanus L. Dihydroconiferyl alcohol can stimulate growth of soybean callus[1].
Eriodictyol 7-O-glucuronide is a flavonoid isolated from Cosmos sulphureus[1].
2,5-Furandicarboxylic acid is a biomass-derived diacid that can be used to make polymers including polyethylene furandicarboxylate (PEF).
(R)-2-Amino-3-(3-(trifluoromethyl)phenyl)propanoic acid is a phenylalanine derivative[1].
H-Ala-Ala-Tyr-OH can be synthesized mutant peptides[1][2].
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-trityl-D-serine is a serine derivative[1].
Dimethyl adipate-d4-1 is the deuterium labeled Dimethyl adipate[1].
WAY-322454 is an active molecule.
Cyclamic acid (Cyclohexylsulfamic acid) sodium is one of the most widely used artificial sweetenersin food and pharmaceuticals[1].
5-Carboxy-X-rhodamin N-succinimidyl ester is a labeling reagent. 5-Carboxy-X-rhodamin N-succinimidyl ester can be used in the preparation of charge-modified dye-labeled Dideoxynucleotide Triphosphates (ddNTP) to "direct-load" DNA sequencing[1].
2’-O,4’-C-Methyleneuridine (Compound 15a) is a bicyclic nucleoside.
3-Aminopropan-1-ol-d6 is the deuterium labeled 3-Aminopropan-1-ol[1].
Megastigm-7-ene-3,4,6,9-tetrol is a natural product that can be isolated from Apollonias barbujana[1].
Epifriedelanol acetate (Compound Ⅲc) is a nature product. Epifriedelanol acetate can be isolated from Pachysandra terminalis Sieb[1].
Menthofuran is a proximate toxic metabolite of (R)-(+)-Pulegone. Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase[1][2].
(2-Fluoro-4-biphenyl)acetic acid-d5 is the deuterium labeled (2-Fluoro-4-biphenyl)acetic acid[1].
BGN3 is a good substrate for the SNAP-tag® and H5 enzymes. The activities of SNAP-tag® and H5 enzymes on BGN3 are reasonable (IC50= 15.6 and 23.5 μM, respectively)[1].
Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2].
Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a substrato peptídico of HIV-1 protease.Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 acts as the variable substrate in a peptidolytic assay to quantify the inhibition of the protease[1][2].
Fast Sulphon Black F is a specific copper indicator. Fast Sulphon Black F can be used for EDTA titration[1].
6-(γ,γ-Dimethylallylamino)purine-d6 is the deuterium labeled 6-(γ,γ-Dimethylallylamino)purine (HY-112103). 6-(γ,γ-Dimethylallylamino)purine is a plant growth substance[1][2].
Sulfo-SMCC sodium is a commonly used hetero-bifunctional crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
16-Nor-15-oxodehydroabietic acid (compound 32) is a compound isolated from the root bark of Pinus massoniana[1].
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methoxy-L-phenylalanine is a phenylalanine derivative[1].
Gum guaiac is a biochemical reagent that can be used as a biological material or organic compound for life science related research.