(16R)-E-Isositsirikine is an indole alkaloid compound from Catharanthus roseus Tissue Cultures IV1[1].
Cholesterol oxidase (ChOx) is a bacterial flavin oxidase containing FAD, commonly used in biochemical research. Cholesterol oxidase catalyzes the oxidation of the C(3)-OH group of cholesterol (and other sterols) to cholest-5-en-3-one and isomerizes it to cholest-4-en-3-one[1].
Fmoc-Lys(5'-FAM)-OH is a lysine derivative[1].
Acenaphthylene-d8 is the deuterium labeled Acenaphthylene[1]. Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter[2].
HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC50 of 0.033 μM[1].
(2R,3S)-2,3,4-Trihydroxybutanal is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
2-Bromoadenosine, antimalarial agent is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Metribuzin is a low-cost non-selective herbicide that belongs to the chemical class of triazinones. Metribuzin hinders DNA synthesis in treated plants and acts on photosystem II, ultimately inhibiting photosynthesis. Metribuzin provides good control of important annual grass and broad-leaf weeds[1].
Netarsudil mesylate is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter; reduces intraocular pressure (IOP) in normotensive monkey eyes.
5,12-Dihydro-12-phenylindolo[3,2-a]carbazole-d16 is a deuterium labeled compound.
3-Methylcatechol is a building block in the chemical synthesis produced by Pseudomonas putida MC2[1].
1-Hexanol-d13 is the deuterium labeled 1-Hexanol[1]. 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties[2]. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism[3].
Trisulfo-Cy5-Alkyne is a click chemistry reagent containing an azide group. Trisulfo-Cy5-Alkyne can participate in copper-catalyzed Click Chemistry reactions. Trisulfo-Cy5-Alkyne is a near infrared (NIR) fluorescent dye[1].
Cholesterol 5beta,6beta-epoxide is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. [1] [2] Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. [3] 5β,6β-epoxycholestanol has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue. [4] References: [1]. Pulfer, MK, and Murphy, RC Formation of bioactive oxygen sterols during ozonolysis of cholesterol present in lung surfactants. Journal of Biochemistry 279(25), 26331-26338 (2004). [2]. Aringer, L. and Eneroth, P. In vitro formation and metabolism of cholesterol and β-sitosterol 5,6-epoxides. J. Lipid Research. 15(4), 389-398 (1974).[3]. Lordan, S., O'Brien, NM, and Mackrill, JJ Calcium in 7β-hydroxycholesterol and cholesterol-5β,6β-epoxide-induced apoptosis. J. Biochemistry. Moore. poison. 23(5), 324-332 (2009).[4]. Garcia-Cruset, S., Carpenter, KL, Guardiola, F. et al. Oxysterol profiles of normal human arteries, fatty streaks, and advanced lesions. free radicals. reservoir. 35(1), 31-41 (2001).
2′-β-C-Methyl-2-methoxyadenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].
Ethylvanillin is a flavorant, about three times as potent as vanillin and is used in the production of chocolate.
NSC194598 is a p53 DNA-binding inhibitor with IC50 value of 180 nM and 2-40 μM for in vitro and in vivo, respectively. NSC194598 interferes with transcriptional activation of mutated RET gene in human medullary thyroid carcinoma TT cells. NSC194598 can be used for acute toxicity to normal tissues by radiation and chemotherapy research[1][2].
Soyasaponin Af (Acetyl-soyasaponin A2) is a saponin isolated from Black bean (Phaseolus vulgaris L.) seed coats[1].
N6-Methyladenosine 5'-monophosphate disodium salt is an activator of glycogen phosphorylase b, with a Ka value of 22 µM[1]. N6-Methyladenosine 5'-monophosphate disodium salt is a non-competitive rat adenylate kinase II inhibitor[2].
D-Lys(Z)-Pro-Arg-pNA is a luminescent substrate of activated protein C (APC). Sequence: D-Lys(Z)-Pro-Arg-pNA.
PLP (178-191) is a biological active peptide. (This is amino acids 178 to 191 fragment of the proteolipid protein (PLP), an immunodominant encephalitogenic epitope in SJL mice, one of two major encephalitogenic epitopes. PLP peptide 178 to 191 was compared with another encephalitogenic peptide, 139 to 151. The day of onset of disease induced by PLP 178 to 191 was earlier, but the incidence, severity, and histologic features were indistinguishable.)
Methyl benzyl-L-valinate hydrochloride is a valine derivative[1].
Parisyunnanoside H is a steroidal saponin isolated from Paris polyphylla Smith var. yunnanensis[1].
1,2'-O-Dimethylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Suc-Gly-Pro-pNA is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1].
O-tert-Butyl-L-threonine tert-butyl ester acetate salt is a threonine derivative[1].
Pentacarboxylporphyrin I dihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
CRAC intermediate 2 is a intermediate compound for CRAC inhibitor synthesis, extracted from patent WO 2013059666A1.
Rochelle potassium sodium tartrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.