Chemsrc provides Others's classification, including all related biologically active compounds cover the research fields of cancer, neuroscience, immunology and other popular diseases, etc.


Anti-infection >
Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HIV HSV Influenza Virus Parasite Reverse Transcriptase RSV SARS-CoV
Antibody-drug Conjugate >
ADC Cytotoxin ADC Linker Drug-Linker Conjugates for ADC PROTAC-linker Conjugate for PAC
Apoptosis >
Apoptosis Bcl-2 Family c-Myc Caspase DAPK Ferroptosis IAP MDM-2/p53 PKD RIP kinase Survivin Thymidylate Synthase TNF Receptor
Autophagy >
Autophagy LRRK2 ULK Mitophagy
Cell Cycle/DNA Damage >
Antifolate APC ATM/ATR Aurora Kinase Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA-PK DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF) G-quadruplex Haspin Kinase HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 Nucleoside Antimetabolite/Analog p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 ROCK Sirtuin SRPK Telomerase TOPK Topoisomerase Wee1
Cytoskeleton >
Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK
Epigenetics >
AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MicroRNA PARP PKC Sirtuin Protein Arginine Deiminase
GPCR/G Protein >
5-HT Receptor Adenosine Receptor Adenylate Cyclase Adiponectin Receptor Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR Dopamine Receptor EBI2/GPR183 Endothelin Receptor GHSR Glucagon Receptor Glucocorticoid Receptor GNRH Receptor GPCR19 GPR109A GPR119 GPR120 GPR139 GPR40 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR MCHR1 (GPR24) Melatonin Receptor mGluR Motilin Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor Prostaglandin Receptor Protease-Activated Receptor (PAR) Ras RGS Protein Sigma Receptor Somatostatin Receptor TSH Receptor Urotensin Receptor Vasopressin Receptor Melanocortin Receptor
Immunology/Inflammation >
Aryl Hydrocarbon Receptor CCR Complement System COX CXCR FLAP Histamine Receptor IFNAR Interleukin Related IRAK MyD88 NO Synthase NOD-like Receptor (NLR) PD-1/PD-L1 PGE synthase Salt-inducible Kinase (SIK) SPHK STING Thrombopoietin Receptor Toll-like Receptor (TLR) Arginase
JAK/STAT Signaling >
EGFR JAK Pim STAT
MAPK/ERK Pathway >
ERK JNK KLF MAP3K MAP4K MAPKAPK2 (MK2) MEK Mixed Lineage Kinase MNK p38 MAPK Raf Ribosomal S6 Kinase (RSK)
Membrane Transporter/Ion Channel >
ATP Synthase BCRP Calcium Channel CFTR Chloride Channel CRAC Channel CRM1 EAAT2 GABA Receptor GlyT HCN Channel iGluR Monoamine Transporter Monocarboxylate Transporter Na+/Ca2+ Exchanger Na+/HCO3- Cotransporter Na+/K+ ATPase nAChR NKCC P-glycoprotein P2X Receptor Potassium Channel Proton Pump SGLT Sodium Channel TRP Channel URAT1
Metabolic Enzyme/Protease >
15-PGDH 5 alpha Reductase 5-Lipoxygenase Acetyl-CoA Carboxylase Acyltransferase Adenosine Deaminase Adenosine Kinase Aldehyde Dehydrogenase (ALDH) Aldose Reductase Aminopeptidase Angiotensin-converting Enzyme (ACE) ATGL ATP Citrate Lyase Carbonic Anhydrase Carboxypeptidase Cathepsin CETP COMT Cytochrome P450 Dipeptidyl Peptidase Dopamine β-hydroxylase E1/E2/E3 Enzyme Elastase Enolase FAAH FABP Factor Xa Farnesyl Transferase Fatty Acid Synthase (FAS) FXR Glucokinase GSNOR Gutathione S-transferase HCV Protease Hexokinase HIF/HIF Prolyl-Hydroxylase HIV Integrase HIV Protease HMG-CoA Reductase (HMGCR) HSP Indoleamine 2,3-Dioxygenase (IDO) Isocitrate Dehydrogenase (IDH) Lactate Dehydrogenase LXR MAGL Mineralocorticoid Receptor Mitochondrial Metabolism MMP Nampt NEDD8-activating Enzyme Neprilysin PAI-1 PDHK PGC-1α Phosphatase Phosphodiesterase (PDE) Phospholipase Procollagen C Proteinase Proteasome Pyruvate Kinase RAR/RXR Renin ROR Ser/Thr Protease SGK Stearoyl-CoA Desaturase (SCD) Thrombin Tryptophan Hydroxylase Tyrosinase Xanthine Oxidase
Neuronal Signaling >
5-HT Receptor AChE Adenosine Kinase Amyloid-β Beta-secretase CaMK CGRP Receptor COMT Dopamine Receptor Dopamine Transporter FAAH GABA Receptor GlyT iGluR Imidazoline Receptor mAChR Melatonin Receptor Monoamine Oxidase nAChR Neurokinin Receptor Opioid Receptor Serotonin Transporter γ-secretase
NF-κB >
NF-κB IKK Keap1-Nrf2 MALT1
PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
Ack1 ALK Bcr-Abl BMX Kinase Btk c-Fms c-Kit c-Met/HGFR Discoidin Domain Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 IGF-1R Insulin Receptor IRAK Itk PDGFR PKA Pyk2 ROS Src Syk TAM Receptor Trk Receptor VEGFR
Stem Cell/Wnt >
Casein Kinase ERK Gli GSK-3 Hedgehog Hippo (MST) JAK Notch Oct3/4 PKA Porcupine ROCK sFRP-1 Smo STAT TGF-beta/Smad Wnt YAP β-catenin γ-secretase
TGF-beta/Smad >
TGF-beta/Smad PKC ROCK TGF-β Receptor
Vitamin D Related >
VD/VDR
Others >
Androgen Receptor Aromatase Estrogen Receptor/ERR Progesterone Receptor Thyroid Hormone Receptor Others

S-Fcme

S-tram,tram-Farnesylated cysteine methyl ester is a multidrug resistance transporter activator. S-tram,tram-Farnesylated cysteine methyl ester acts by stimulating the multidrug resistance transporter ATPase activity and competing for drug binding[1].

  • CAS Number: 125741-64-2
  • MF: C19H33NO2S
  • MW: 339.54
  • Catalog: Others
  • Density: 0.987g/cm3
  • Boiling Point: 446.7ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 223.9ºC

(2H40)Nonadecane

n-Nonadecane-d40 is the deuterium labeled Nonadecane[1].

  • CAS Number: 39756-36-0
  • MF: C19D40
  • MW: 308.767
  • Catalog: Others
  • Density: 0.8±0.1 g/cm3
  • Boiling Point: 330.1±5.0 °C at 760 mmHg
  • Melting Point: 28-30ºC(lit.)
  • Flash Point: 168.3±0.0 °C

Biotin-11-dUTP

Biotin-11-dUTP is a fluorescent substitute for dTTP.

  • CAS Number: 86303-25-5
  • MF: C28H45N6O17P3S
  • MW: 862.67
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

BDY TMR-X,SE

BODIPY TMR-X SE is a potent fluorescent dye. BODIPY TMR-X SE can be used to label the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY TR-X binds to protein or antibody and has bright, orange fluorescent light. (λex=544 nm, λem=570 nm)[1][2].

  • CAS Number: 217190-15-3
  • MF: C31H35BF2N4O6
  • MW: 608.44
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone

3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone is a nature product that could be isolated from the fruits of Vitex rotundifolia. 3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone has potent cytotoxic activity against A549 and HepG-2 cell lines[1].

  • CAS Number: 90850-99-0
  • MF: C18H18O7
  • MW: 346.33132
  • Catalog: Cancer
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

LJP 1586

LJP 1586 is an amine-based inhibitor of semicarbazide-sensitive amine oxidase (SSAO) activity. LJP 1586 is an orally active, potent and selective inhibitor of rodent and human SSAO activity, with IC50 values between 4 and 43 nM[1].

  • CAS Number: 955037-42-0
  • MF: C11H15ClFNO
  • MW: 231.69
  • Catalog: Inflammation/Immunology
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

RE 1492

RE 1492 is a durch oligoamine insbesonder. RE 1492 inhibits red blood cells impairment of functions when storage[1].

  • CAS Number: 112169-14-9
  • MF: C39H51N3
  • MW: 561.84200
  • Catalog: Others
  • Density: 1.03g/cm3
  • Boiling Point: 698ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 400.8ºC

maesopsin

Maesopsin is a phenolic compound, that can be isolated from Hoveniae Lignum[1].

  • CAS Number: 5989-16-2
  • MF: C15H12O6
  • MW: 288.25200
  • Catalog: Others
  • Density: 1.646g/cm3
  • Boiling Point: 620ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 239.9ºC

(Diacetyl)-α-MSH trifluoroacetate salt

(Diacetyl)-α-MSH is a peptide compound, which introduces an oxalyl (Diacetyl) group into the α-MSH molecule, which can increase the biological activity of the polypeptide[1].

  • CAS Number: 71952-90-4
  • MF: C79H111N21O20S
  • MW: 1706.92
  • Catalog: Others
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

4'-Methylacetophenone

4′-methylacetophenone can be used as a fragrance material. 4′-Methylacetophenone is wildly occurs in volatile compounds in food and in some natural complex substances (NCS)[1].

  • CAS Number: 122-00-9
  • MF: C9H10O
  • MW: 134.175
  • Catalog: Others
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 211.0±9.0 °C at 760 mmHg
  • Melting Point: 45-49 °C(lit.)
  • Flash Point: 92.2±0.0 °C

NaPi2b-IN-3

NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC50s of 71 nM and 28 nM for human NaPi2b and rat NaPi2b, respectively. NaPi2b-IN-3 can be used for researching hyperphosphatemia[1].

  • CAS Number: 2227443-66-3
  • MF: C45H51N5O7
  • MW: 773.92
  • Catalog: Metabolic Disease
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Cyanazine-d5

Cyanazine-d5 is deuterium labeled Cyanazine. Cyanazine, a triazine herbicide cyanazine, is used to control a variety of grass weeds and broadleaf weed. Cyanazine is proved non-genotoxic[1].

  • CAS Number: 1190003-29-2
  • MF: C9H8D5ClN6
  • MW: 245.72
  • Catalog: Others
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 442.4±47.0 °C at 760 mmHg
  • Melting Point: 167.5-1690C
  • Flash Point: 221.4±29.3 °C

(Asp76)-pTH (39-84) (human) trifluoroacetate salt

(Asp76)-pTH (39-84) (human) is a biologically active peptide.

  • CAS Number: 79804-72-1
  • MF: C139H234N46O46
  • MW: 3285.626
  • Catalog: Others
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Sex Pheromone Inhibitor iPD1 trifluoroacetate salt

Sex Pheromone Inhibitor iPD1 is a sex pheromone inhibitor. Sex Pheromone Inhibitor iPD1 inhibits the sex pheromone cPD1[1].

  • CAS Number: 120116-56-5
  • MF: C39H72N8O11
  • MW: 829.03600
  • Catalog: Others
  • Density: 1.163g/cm3
  • Boiling Point: 1160.5ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 655.7ºC

dansyl-l-isoleucine

Dansyl-L-isoleucine is an isoleucine derivative[1].

  • CAS Number: 1100-21-6
  • MF: C18H24N2O4S
  • MW: 364.45900
  • Catalog: Others
  • Density: 1.256g/cm3
  • Boiling Point: 545ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 283.4ºC

tsh

Thyrotropin (TSH) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid[1][2].

  • CAS Number: 9002-71-5
  • MF: C18H26N6O6
  • MW: 422.436
  • Catalog: Endocrinology
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

FGIN-1-43

FGIN 1-43 is an effective and specific ligand for the mitochondrial diazepam binding inhibitor (DBI) receptor (related to the production of neurosteroids). FGIN 1-43 enhances the transmission of GABA by inducing the production of neurosteroids, which can be used for research on anti-anxiety[1].

  • CAS Number: 145040-29-5
  • MF: C28H36Cl2N2O
  • MW: 487.50
  • Catalog: Neurological Disease
  • Density: 1.143g/cm3
  • Boiling Point: 648.5ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 346ºC

1-(1-(4-Chlorophenyl)cyclobutyl)-3-methylbutan-1-amine-d7

1-(1-(4-Chlorophenyl)cyclobutyl)-3-methylbutan-1-amine-d7 is the deuterium labeled 1-(1-(4-Chlorophenyl)cyclobutyl)-3-methylbutan-1-amine[1].

  • CAS Number: 1188331-25-0
  • MF: C15H15D7ClN
  • MW: 258.84
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

H-Gly-Sar-OH

Gly-Sar is a Glycine (HY-Y0966) derivative[1].

  • CAS Number: 29816-01-1
  • MF: C5H10N2O3
  • MW: 146.14400
  • Catalog: Others
  • Density: 1.284g/cm3
  • Boiling Point: 333.5ºC at 760mmHg
  • Melting Point: 198-202 °C (dec.)
  • Flash Point: 155.5ºC

Nisotirostide

Nisotirotide (LY-3457263) is a PYY analog agonist studied in type 2 diabetes and obesity[1].

  • CAS Number: 2663844-45-7
  • MF: C230H343N59O65
  • MW: 4974.53
  • Catalog: Metabolic Disease
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

H-Glu(Leu-OH)-OH

H-γ-Glu-Leu-OH is a dipeptide consisting of γ-glutamic acid and leucine, terminated by a hydroxyl group[1].

  • CAS Number: 2566-39-4
  • MF: C11H20N2O5
  • MW: 260.29
  • Catalog: Others
  • Density: 1.238g/cm3
  • Boiling Point: 550.6ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: N/A

Z-Phe-Leu

Z-Phe-Leu-OH (NSC 334018) is a substrate for carboxypeptidase Y (CPY). Z-Phe-Leu-OH is incubated with recombinant CPY to determine peptidase activity[1].

  • CAS Number: 4313-73-9
  • MF: C23H28N2O5
  • MW: 412.47900
  • Catalog: Others
  • Density: 1.193g/cm3
  • Boiling Point: 674.4ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 361.7ºC

SARS-CoV-2 nsp3-IN-2

SARS-CoV-2 nsp3-IN-2 is a macrodomain (Mac1) inhibitor with IC50 value of 180 μM. SARS-CoV-2 nsp3-IN-2 is a small molecule chemical probe and can be used for the research of viral[1].

  • CAS Number: 2038858-11-4
  • MF: C10H12N4O2
  • MW: 220.23
  • Catalog: Infection
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Fructo-oligosaccharide DP11/GF10

Fructo-oligosaccharide DP11/GF10 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=11). Fructo-oligosaccharides (FOS) are composed of 10 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end[1].

  • CAS Number: 137405-36-8
  • MF: C66H112O56
  • MW: 1801.57
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Emeramide

Emeramide is a novel lipid-soluble, thiol-redox antioxidant and heavy metal chelator.

  • CAS Number: 351994-94-0
  • MF: C12H16N2O2S2
  • MW: 284.398
  • Catalog: Cancer
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 568.9±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 297.9±28.7 °C

WNK463

WNK463 is an orally bioavailable pan-WNK-kinase inhibitor with IC50s of 5, 1, 6, and 9 nM for WNK1, WNK 2, WNK 3, and WNK 4, respectively.

  • CAS Number: 2012607-27-9
  • MF: C21H24F3N7O2
  • MW: 463.456
  • Catalog: Cancer
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Fmoc-L-Lys(Boc,iPr)-OH

Fmoc-Lys(ipr,Boc)-OH is a lysine derivative[1].

  • CAS Number: 201003-48-7
  • MF: C29H38N2O6
  • MW: 510.622
  • Catalog: Others
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 677.1±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 363.3±31.5 °C

Dabcyl acid

Dabcyl acid (Dabcyl) is the original dark fluorescence quencher.

  • CAS Number: 6268-49-1
  • MF: C15H15N3O2
  • MW: 269.29900
  • Catalog: Others
  • Density: 1.17g/cm3
  • Boiling Point: 482.6ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 245.6ºC

Pan-RAF kinase inhibitor 1

Pan-RAF kinase inhibitor 1 is a potent inhibitor of Pan-RAF kinase. Pan-RAF kinase inhibitor 1 regulates MAPK signaling by inhibiting RAF kinase, thereby exerting an effect on the proliferation of RAS-mutant tumor cells. Pan-RAF kinase inhibitor 1 has the potential for the research of cancer diseases (extracted from patent WO2021110141A1, compound 16B)[1].

  • CAS Number: 2648838-76-8
  • MF: C26H24F3N3O4
  • MW: 499.48
  • Catalog: Cancer
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Thalidomide-NH-CH2-COO(t-Bu)

Thalidomide-NH-CH2-COO (t-Bu) is a molecular block of small-molecule degrader[1].

  • CAS Number: 2093386-23-1
  • MF: C19H21N3O6
  • MW: 387.39
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A