N1,N1'-(Propane-1,3-diyl)bis(propane-1,3-diamine)-d24 is the deuterium labeled N1,N1'-(Propane-1,3-diyl)bis(propane-1,3-diamine)[1].
Hyperoside, a natural flavonoid, isolated from Camptotheca acuminate, possesses antifungal, anti-inflammatory, anti-viral, anti-oxidative and anti-apoptotic activities[1].
Favezelimab (MK-4280) is a humanized anti-LAG-3 monoclonal antibody that blocks the interaction between LAG-3 and its ligand MHC class II. Favezelimab has the potential for colorectal cancer (CRC) research combined with the PD-L1 inhibitor Pembrolizumab (HY-P9902)[1][2].
1,5,5-Trimethylhydantoin (TMH) is a non-isotopic internal standard (IS)[1].
Thymoquinone is a nature product isolated from N. sativa. Thymoquinone possess antioxidant, anti-inflammatory, anti-cancer, antitumor activities and hepatoprotective properties[1].
Fluorofurimazine is fluorogenic substrate for Antares. Fluorofurimazine can realize sensitive bioluminescence imaging to prolong the generation of high-sensitivity light. Fluorofurimazine has good aqueous solubility allows delivery of higher doses to mice. Fluorofurimazine can be used in the bioluminescence imaging[1].
Lucinactant is a novel synthetic peptide that functionally mimics surfactant protein B, a protein with anti-inflammatory properties. Lucinactant is a KL4-Surfactant, protects human airway epithelium from hyperoxia[1][2][3].
Dihydroactinidiolide, existing in plant leaves and fruits, is a potent plant growth inhibitor, a regulator of gene expression and is responsible for photo acclimation in Arabidopsis. Dihydroactinidiolide has antioxidant activity, antibacterial activity, anticancer activity and neuroprotective effect[1].
(±)-1,2-Propanediol is an aliphatic alcohol and frequently used as an excipient in many drug formulations to increase the solubility and stability of drugs.
ER-Tracker Blue-White DPX is a photostable probe used to selectively label the endoplasmic reticulum for fluorescence microscopy imaging[1].
D-Glucuronamide is the derivate of D-glucuronic acid[1].
11-epi-mogroside V is a mogroside in the fruit of Siraitia grosvenori. 11-epi-mogroside V exhibits considerable bioactivity in promoting glucose uptake in human HepG2 cells in vitro [1].
Homoarbutin is a phenolic glycoside isolated from the whole plants of Pyrola japonica[1].
SJA710-6 is a small molecule able to selectively differentiate MSCs toward hepatocyte-like cells[1].
Dodecylphosphocholine-d25 is the deuterium labeled Dodecylphosphocholine[1]. Dodecylphosphocholine is a detergent widely utilized in NMR studies of membrane proteins[2][3].
3-(3-Ethoxy-4-methoxyphenyl)propionic-2,2,3,3-d4 is the deuterium labeled 3-(3-Ethoxy-4-methoxyphenyl)propionic[1].
Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside is a flavanone compound.
DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) disodium is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor[1][2].
Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of drugs and metabolites[1].
Gelsevirine is the major alkaloid in Gelsemium elegans with potent anxiolytic effects. The anxiolytic mechanism of Gelsevirine may be involved in the agonist action of the glycine receptor in the brain. Gelsevirine has anti-proliferation activity with IC50 values of 1.41 mM and 1.22 mM for SW480 cells and MGC80-3 cells, respectively[1][2][3].
Mal-AMCHC-N-Propargylamide is a click chemistry reagent containing an azide group. Mal-AMCHC-N-Propargylamide can be a bio-conjugation reagent for antibody-drug-conjugate synthesis using Click-Chemistry[1].
ACBI3 (compound 7) is a pan-KRAS degrader. ACBI3 achieves in vivo degradation of oncogenic KRAS[1].
Benzydamine N-Oxide is a metabolite of Benzydamine. Benzydamine N-Oxide can be used to measure flavin-containing monooxygenase activity[1][2].
4-Nitrophenyl β-D-Cellobioside (p-Nitrophenyl β-D-cellobioside) is a cellotriose analog, a chromogenic substrate for the detection of cellulase activity. Exoglucanases, endoglucanases, and β-glucosidases hydrolyze 4-Nitrophenyl β-D-Cellobioside to yield p-nitrophenol (PNP)[1][2].
α-Glucosidase-IN-37 (Compound 11) moderately inhibits LPS-induced NO production with an IC50 value of 23.7 μM in macrophages. α-Glucosidase-IN-37 has weak inhibitory activity against α-Glucosidase[1].
Podocarpusflavone B is a bisflavone that can be isolated from Padocarpus macraphylla[1].
7-Hydroxy-4-methyl-8-nitrocoumarin is a coumarin derivative[1].
(25R)-Officinalisnin-II (compound 5) is a furostanol glycoside found in the fruits of Asparagus curillus[1].
Megastigm-7-ene-3,5,6,9-tetraol (Megastigma-7-en-3,5,6,9-tetraol) is a diterpenoid analogue in the aerial parts of Isodon melissoides. Megastigm-7-ene-3,5,6,9-tetraol is also in Vigna luteola and has anti-inflammatory bioactivity[1][2].
Agouti-Related Protein (25-51) (human) (AGRP (25-51) (human)) is an amino-terminal 25-51 fragment of agouti-related protein (AGRP)[1].