Inarigivir (ORI-9020;SB-9000) is a dinucleotide which can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus.
Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia silvestris, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity.
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis tyrosinase inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds[1].
Mal-PEG2-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
VX-661 is a second F508del CFTR corrector and help CFTR protein reach the cell surface.
Neokurarinol is a natural flavonoid compound[1].
N-Benzoyl-Gly-His-Leu hydrate is a leucine derivative, a polypeptide. N-Benzoyl-Gly-His-Leu hydrate exerts function with angiotensin converting enzyme (ACE) substrate.
Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes[1].
Cys(Npys) Antennapedia Peptide, amide is a peptide. Cys(Npys) Antennapedia Peptide, amide can be used for various biochemical studies[1].
Brilacidin is a nonpeptidic anti-infective in a new class of defensin mimetics that is being developed for the treatment of eye infections.
Larotrectinib (LOXO-101) sulfate is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).
Probucol Disuccinate is a derivative of Probucol, a lipid-regulating agent and can reduce LDL-cholesterol levels[1].
(R)-Nedisertib ((R)-M3814) is a less active R-enantiomer of Nedisertib, with an IC50 in the range of 7-30 nM for DNA-PK[1].
(Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1.
S18-000003 is a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor with an IC50 of 29 nM. S18-000003 inhibits IL-17 production[1].
Fmoc-N-(1-Boc-4-piperidyl)glycine is a Glycine (HY-Y0966) derivative[1].
Fmoc-L-Dap(Poc)-OH is a click chemistry reagent containing an azide group. Amino acid building block suitable for side chain Click conjugation with standard protocols and together with tetrazine linkers in copper-free Click conjugation (Diels-Alder)[1].
HIF-2α-IN-6 (117) is a HIF-2α inhibitor[1].
Enilconazole is a fungicide, widely used in agriculture, particularly in the growing of citrus fruits, also used in veterinary medicine as a topical antimycotic.
GPR120 Agonist 2 is a GPR120 agonist extracted from patent US 20110313003 A1, example 209.
(E)-AG 99 ((E)-Tyrphostin 46; (E)-Tyrphostin AG 99) is a potent EGFR inhibitor[1].
Fmoc-Glu(O-2-PhiPr)-OH is a glutamic acid derivative[1].
Sotalol D6 hydrochloride is a deuterium labeled Sotalol hydrochloride. Sotalol hydrochloride is a non-selective competitive β-adrenergic receptor antagonist that also exhibits Class III antiarrhythmic properties by its inhibition of potassium channels[1][2].
Miocamycin (Midecamycin acetate) is a derivative of midecamycin (HY-B1908), a macrolide antibiotic that can be isolated from a culture broth of Streptomyces mycarofaciens. Miocamycin has antibacterial properties[1].
Phthalamide-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
DMT-2'-O-MOE-rA(Bz) phosphoramidite is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].
Isoprenaline hydrochloride is a non-selective beta-adrenergic receptor agonist with potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities.
A7132 is an antibacterial agent. A7132 possess broad and potent antibacterial activity.
Caveolin-1 (82-101) amide (human, mouse, rat) (Caveolin-1 scaffolding domain peptide) is a peptide that reverses aging-associated deleterious changes in multiple organs. Caveolin-1 (82-101) amide (human, mouse, rat) inhibits tyrosine kinases[1].
p-Hydroxy-5,6-dehydrokawain is a natural compound isolated from Kawain[1].