Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of both insulin and leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.


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Apoptosis >
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15-PGDH 5 alpha Reductase 5-Lipoxygenase Acetyl-CoA Carboxylase Acyltransferase Adenosine Deaminase Adenosine Kinase Aldehyde Dehydrogenase (ALDH) Aldose Reductase Aminopeptidase Angiotensin-converting Enzyme (ACE) ATGL ATP Citrate Lyase Carbonic Anhydrase Carboxypeptidase Cathepsin CETP COMT Cytochrome P450 Dipeptidyl Peptidase Dopamine β-hydroxylase E1/E2/E3 Enzyme Elastase Enolase FAAH FABP Factor Xa Farnesyl Transferase Fatty Acid Synthase (FAS) FXR Glucokinase GSNOR Gutathione S-transferase HCV Protease Hexokinase HIF/HIF Prolyl-Hydroxylase HIV Integrase HIV Protease HMG-CoA Reductase (HMGCR) HSP Indoleamine 2,3-Dioxygenase (IDO) Isocitrate Dehydrogenase (IDH) Lactate Dehydrogenase LXR MAGL Mineralocorticoid Receptor Mitochondrial Metabolism MMP Nampt NEDD8-activating Enzyme Neprilysin PAI-1 PDHK PGC-1α Phosphatase Phosphodiesterase (PDE) Phospholipase Procollagen C Proteinase Proteasome Pyruvate Kinase RAR/RXR Renin ROR Ser/Thr Protease SGK Stearoyl-CoA Desaturase (SCD) Thrombin Tryptophan Hydroxylase Tyrosinase Xanthine Oxidase
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Vitamin D Related >
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PROTAC PTPN2 degrader-1

PROTAC PTPN2 degrader-1 (compound example 77) is a potent PTPN2 degrader. PROTAC PTPN2 degrader-1 has the potential for the research of cancer or metabolic disease[1].

  • CAS Number: 2655638-07-4
  • MF: C33H27FN6O8S
  • MW: 686.67
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Sodium orthovanadate

Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.

  • CAS Number: 13721-39-6
  • MF: Na3O4V
  • MW: 183.908
  • Catalog: Biochemical Assay Reagents
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 850-866 °C(lit.)
  • Flash Point: N/A

Azadirachtin B

Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties[1][2][3].

  • CAS Number: 106500-25-8
  • MF: C33H42O14
  • MW: 662.678
  • Catalog: Influenza Virus
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 780.5±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 246.6±26.4 °C

SHP2-IN-8

SHP2-IN-8 is a highly potent, selective, and cellularly active allosteric SHP2 inhibitor with IC50 value of 23 nM and Ki of 22 nM. SHP2-IN-8 is reversible and noncompetitive. SHP2-IN-8 causes a significant thermal shift with the ΔTm of 7.01 ℃. SHP2-IN-8 induces the apoptosis and inhibits the phosphorylation of AKT in Hela cells[1].

  • CAS Number: 1801692-60-3
  • MF: C17H21Cl2N5S
  • MW: 398.35
  • Catalog: Apoptosis
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

JUN-1111

JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1[1][2].

  • CAS Number: 874351-38-9
  • MF: C15H17N3O3
  • MW: 287.31400
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

SBI-425

SBI-425 is a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor[1]. Long-term administration of SBI-425 effectively reaches and inhibits TNAP in the vasculature, improving cardiovascular parameters and survival at a dose that does not cause a detectable change in bone[2].

  • CAS Number: 1451272-71-1
  • MF: C13H12ClN3O4S
  • MW: 341.77
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

LYP-IN-1

LYP-IN-1 is a potent, selective and specific LYP inhibitor with a Ki and an IC50 of 110 nM and 0.259 μM, respectively. LYP-IN-1 also has selectivity for a large panel of PTPs, such as SHP1 (IC50=5 μM) and SHP2 (IC50=2.5 μM). LYP-IN-1 exhibits highly efficacious cellular activity in T- and mast cells. LYP-IN-1 can be used for the study of autoimmune disorders[1].

  • CAS Number: 1404436-51-6
  • MF: C28H20ClNO6
  • MW: 501.91
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

SHP2 inhibitor LY6

SHP2 inhibitor LY6 (LY6) is potent and selective inhibitor of SHP2, with an IC50 of 9.8 µM. SHP2 inhibitor LY6 can inhibits SHP2-mediated cell signaling and proliferation[1].

  • CAS Number: 2296718-09-5
  • MF: C30H27Cl2N3O4
  • MW: 564.46
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Cyclosporin A-Derivative 3

Cyclosporin A-Derivative 3 is a derivative of Cyclosporin A (HY-B0579) with calcineurin inhibition[1].

  • CAS Number: 121584-34-7
  • MF: C63H111N11O12
  • MW: 1214.62
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

BCI

BCI is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI does not inhibit DUSP5[1].

  • CAS Number: 1245792-51-1
  • MF: C22H23NO
  • MW: 317.424
  • Catalog: Phosphatase
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 484.6±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 161.3±28.9 °C

Calcium 2,3-dihydroxypropyl phosphate

Calcium glycerophosphate is an inhibitor of intestinal alkaline phosphatase F3. Calcium glycerophosphate is a source of calcium and phosphorus in total parenteral nutrition solutions[1][2].

  • CAS Number: 27214-00-2
  • MF: C3H7CaO6P
  • MW: 210.136
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: 485.5ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 247.4ºC

orellanine

Orellanine is a fungal nephrotoxin. Orellanine is also a competitive inhibitor of alkaline phosphatase. Orellanine induces cell death in proximal tubular cells and in ccRCC cells. Orellanine can be used for research of clear cell renal cell carcinoma (ccRCC)[1][2].

  • CAS Number: 37338-80-0
  • MF: C10H8N2O6
  • MW: 252.18
  • Catalog: Phosphatase
  • Density: 1.777 g/cm3
  • Boiling Point: 834.615ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 458.558ºC

SPI-112

SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively[1][2].

  • CAS Number: 1051387-90-6
  • MF: C22H17FN4O5S
  • MW: 468.45
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Trimyristin--d15

Trimyristin--d15 is the deuterium labeled Trimyristin. Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively[1].

  • CAS Number: 1219804-94-0
  • MF: C45H71D15O6
  • MW: 738.25
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

TNO155

TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors[1].

  • CAS Number: 1801765-04-7
  • MF: C18H24ClN7OS
  • MW: 421.95
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

BVT 948

BVT948 is a protein tyrosine phosphatase (PTP) inhibitor which can also inhibit several cytochrome P450 (P450) isoforms and lysine methyltransferase SETD8.

  • CAS Number: 39674-97-0
  • MF: C14H11NO3
  • MW: 241.24200
  • Catalog: Histone Methyltransferase
  • Density: 1.39g/cm3
  • Boiling Point: 400.8ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 196.2ºC

Disodium tartrate dihydrate

Tartaric acid disodium dihydrate is a Acid phosphatase inhibitor, is a sodium salt used in buffers for molecular biology and cell culture applications. Increases the rate of colchicine binding to tubulin1.

  • CAS Number: 6106-24-7
  • MF: C4H10Na2O8
  • MW: 232.10
  • Catalog: Biochemical Assay Reagents
  • Density: 1,82 g/cm3
  • Boiling Point: 399.3ºC at 760 mmHg
  • Melting Point: 150°C -2H₂O
  • Flash Point: 209.4ºC

L-Ascorbic Acid 2-phosphate (magnesium salt hydrate)

L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) magnesium hydrate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate magnesium hydrate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate magnesium hydrate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[1][2][3].

  • CAS Number: 1713265-25-8
  • MF: C12H12Mg3O18P2·xH2O
  • MW:
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

h-NTPDase8-IN-1

h-NTPDase8-IN-1 (compound 2d) is a sulfamoyl-benzamides based and selective inhibitor for h-NTPDases8 (IC50=0.28 μM). h-NTPDases8 is involved in a variety of physiological and pathological functions,such as thrombosis,diabetes,inflammation,and cancer[1].

  • CAS Number: 716358-51-9
  • MF: C10H10ClNO4S
  • MW: 275.71
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

NAPHTHOL AS-GR PHOSPHATE DISODIUM

Naphthol AS-GR phosphate disodium is substrates for acid and alkaline phosphatases. Naphthol AS-GR phosphate disodium has an intense green fluorescence used in histochemical studies[1].

  • CAS Number: 100929-51-9
  • MF: C22H16NNa2O5P
  • MW: 451.31900
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

BIS(4-METHYL-1-PIPERAZINYLTHIOCARBONYL) DISULFIDE

EWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4)P2 phosphatase and Ins(1,4,5)P3 5-phosphatase. EWP 815 also inhibits enzyme dopamine β-hydroxylase activity[1][2].

  • CAS Number: 20231-01-0
  • MF: C12H22N4S4
  • MW: 350.59000
  • Catalog: Phosphatase
  • Density: 1.339g/cm3
  • Boiling Point: 450.5ºC at 760 mmHg
  • Melting Point: 142ºC
  • Flash Point: 226.3ºC

IACS-15414

IACS-15414 is a potent and orally bioavailable SHP2 inhibitor with an IC50 value of 122 nM.

  • CAS Number: 2411321-29-2
  • MF: C20H24Cl2N4O2
  • MW: 423.34
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Rilapladib

Rilapladib is a selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) inhibitor with an IC50 of 230 pM.

  • CAS Number: 412950-08-4
  • MF: C40H38F5N3O3S
  • MW: 735.80500
  • Catalog: Phosphatase
  • Density: 1.36g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Enocyanin

Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity[1].

  • CAS Number: 11029-12-2
  • MF: C15H11O
  • MW: 207.247
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

cis-Ferulic acid 4-O-β-D-glucopyranoside

cis-Ferulic acid 4-O-β-D-glucopyranoside (compound 7) is a phenolic glycosid, which can be isolated from Nitraria sibirica.. cis-Ferulic acid 4-O-β-D-glucopyranoside exhibits antioxidant activity and potent inhibitory effect on Phosphatase PTP1B[1].

  • CAS Number: 94942-20-8
  • MF: C16H20O9
  • MW: 356.32
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

SHP2 protein degrader-2

SHP2 protein degrader-2 (SHP2-D26) is a SHP2 protein PROTAC degrader. SHP2 protein degrader-2 reduces expression level of SHP2 in various cancer cells[1].

  • CAS Number: 2740582-16-3
  • MF: C56H79ClN12O6S2
  • MW: 1115.89
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

ASB 14780

ASB 14780 (ASB14780, ASB-14780) is a potent, selective and orally active cytosolic phospholipase A2α (cPLA2α) inhibitor with IC50 of 20 nM; displays excellen selectivity over other known secreted phospholipase A2s (sPLA2s), such as sPLA2-IA, sPLA2-IIA, sPLA2-III, and sPLA2-IB; markedly ameliorates liver injury and hepatic fibrosis, attenuates the CCl4-induced expression of α-SMA protein and the mRNA expression of collagen 1a2, α-SMA, and TGF-β1 in the liver, and inhibits the expression of monocyte/macrophage markers, CD11b and MCP-1 in vivo, while preventing the recruitment of monocytes/macrophages to the liver.

  • CAS Number: 1069046-00-9
  • MF: C31H27NO3·C4H11NO3
  • MW: 582.686
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

PTPN22-IN-1

PTPN22-IN-1 is a potent PTPN22 inhibitor (IC50=1.4 µM; Ki=0.50 µM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses[1]. From WO2021007491A1 compound L-1.

  • CAS Number: 2580935-57-3
  • MF: C26H21N3O5
  • MW: 455.46
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Calyculin A

Calyculin A is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.5 to 1 nM.

  • CAS Number: 101932-71-2
  • MF: C50H81N4O15P
  • MW: 1009.17000
  • Catalog: Phosphatase
  • Density: 1.25g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

TCS 401

TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

  • CAS Number: 243966-09-8
  • MF: C10H11ClN2O5S
  • MW: 306.723
  • Catalog: Phosphatase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A