PACAP (6-38), human, ovine, rat is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively.
PrDiAzK is a bifunctional amino acid. PrDiAzK can be site-selectively incorporated into proteins in both bacterial and mammalian cell culture. PrDiAzK can be used for proteome-wide incorporation via stochastic orthogonal recoding of translation (SORT)[1].
Piperundecalidine is an amide alkaloids that can be purified from Piper longum L. Piperundecalidine shows various biological properties, such as anti-inammatory, analgesic, anti-amoebic, anti-depressant, hepatoprotective,etc.[1].
TUG-891 is a potent and selective agonist of the long chain free fatty acid (LCFA) receptor 4.
BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation)[1].
Tanshindiol B, a naphthaquinone diterpene, inhibits GBM growth by induction of noptosis (NQO1-dependent necrosis)[1].
Lacto-N-neodifucohexaose II (Compd 9) is a derivative of key human milk tetrasaccharide[1].
D-Ribose 1,5-diphosphate (D-Ribulose-1,5-bisphosphate) is a pentaglucose, it plays an important role in the Calvin cycle of photosynthesis[1].
Xanthocillin X permethyl ether is a natural compound isolated from fungal extracts, with Aβ-42 lowering activity[1].
AMPPD, 1,2 - dioxo-cyclohexane derivatives, is a new biochemistry ultrasensitive alkaline phosphatase substrate.
Oxythiamine, an antimetabolite and a vitamin B1 antagonist, is a well-known thiamine antagonist and inhibitor of transketolase.
4-Fluororesorcinol is a precursor used in the preparation of fluorescent dyes or indicators such as fluorescein, coumarin and resorcinol analogues[1].
2,6-Dimethoxyphenol-d3 is the deuterium labeled 2,6-Dimethoxyphenol[1]. 2,6-Dimethoxyphenol is a phenolic compound that is extensively used for the measurement of laccase activity[2].
CMP-sialic acid synthetase (CSS) is an essential enzyme involved in the biosynthesis of carbohydrates and glycoconjugates containing sialic acids. CMP-sialic acid synthetase activates free Sia, converting it to CMP-Sia, which is the only donor substrate for all sialyltransferases[1].
Lup-20(29)-en-28-oic acid, a triterpenoid saponins of Pulsatilla koreana Root, possesses anti-inflammatory and anti-tumor effect[1][2].
Mono-n-Pentyl Phthalate-3,4,5,6-d4 is the deuterium labeled Mono-n-Pentyl Phthalate[1].
(R)-2,3-Dihydroxypropanal-d is the deuterium labeled (R)-2,3-Dihydroxypropanal[1].
Ferroportin-IN-1 is a ferroportin inhibitor extracted from patent WO2020123850A1 compound 23. Ferroportin-IN-1 can be used for the research of diseases caused by a lack of hepcidin or iron metabolism disorders[1].
A novel potent, in vivo-active BCL6 inhibitor with IC50 of 0.1 uM in ELISA assays; exhibits good cellular BCL6BTB/ BCoR PPI inhibitory activity in the submicromolar range (M2H IC50=0.72 uM), showed a good pharmacokinetic profile, which is acceptable for both in vitro and in vivo studies.
Andrographiside is a labdane diterpenoid glucoside that can be isolated from the leaves of Andrographis paniculata Nees. Andrographiside has antihepatotoxic and antioxidative effects. Andrographiside shows protective effects on mice with hepatotoxicity induced by carbon tetrachloride or tert-butylhydroperoxide (tBHP)[1].
WAY-324572 is an active molecule.
Activated A Subunit can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 51 jumping. It can be used for research of muscular dystrophy[1].
Kaempferol-3-O-(2''-O-β-D-glucopyl)-β-D-rutinoside is a natural glycoside that could be found in Camellia oleifera seeds[1].
Histone H3 (1-20) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1].
((2,4,6-Triisopropylphenyl)sulfonyl)-L-serine is a serine derivative[1].
Lucifer Yellow CH dipotassium is a highly fluorescent dye. Lucifer Yellow CH dipotassium can be viewed both in living tissue and after fixation and embedding. Lucifer Yellow CH dipotassium can be used for marking cells. Lucifer Yellow CH dipotassium spreads rapidly throughout an injected cell. Lucifer Yellow CH dipotassium has a great intrinsic tendency to spread from cell to cell (Ex/Em=430/540 nm)[1][2].
2-(trans-1,4-Dihydroxy-cyclohexyl)-5,7-dihydroxy-chromone is a flavone derivative that can be found in macrothelypteris torresiana. 2-(trans-1,4-Dihydroxy-cyclohexyl)-5,7-dihydroxy-chromone shows cytotoxic[1].
MM 54 is a potent apelin receptor antagonist (Ki=82 nM, IC50=93 nM). MM 54 antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. MM 54 recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.
4-Acetylsimvastatin is an acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[1].