M8 metabolite of Carvedilol-d5 is the deuterium labeled M8 metabolite of Carvedilol[1].
Flucycloxuron (Andalin) is an insect growth regulator (IGR)[1].
Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside] is a cardenolide isolated from the root barks of Periploca sepium[1].
2',3',5'-Tri-O-benzoyl-5-azacytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].
Icariside E4 is an antinociceptive agent, and can be isolated from Tabebuia roseo-alba. Icariside E4 has peripheral analgesic activity by ATP-sensitive K+ channel-dependent mechanisms. Icariside E4 also has anti-oxidant, anti-Alzheimer and anti-inflammatory effects[1][2].
Isonipecotic acid-d9 is the deuterium labeled Isonipecotic acid[1]. Isonipecotic acid is a GABAA receptor partial agonist[2].
Anabaseine, an alkaloid, stimulates a wide variety of animal nicotinic acetylcholine receptors (AChRs), especially the neuromuscular receptors and α7 AChRs[1].
Tepilamide fumarate (XP-23829) is an oral fumaric acid ester, acts as a prodrug of monomethyl fumarate, and is used in the research of moderate to severe chronic plaque psoriasis[1].
[Leu5]-Enkephalin, amide is a δ opioid receptor agonist.
Darexaban (YM150) is a potent, selective and orally active factor Xa (FXa) inhibitor with an IC50 of 54.6 nM. Darexaban shows high selectivity against other related serine proteases, such as trypsin, thrombin, and kallikrein. Darexaban has anticoagulant and antithrombotic effects[1][2][3].
Methyl α-D-mannopyranoside could target macrophages in anti-tuberculosis inhalation therapy[1].
UAA crosslinker 1 act as substrates for pylRS/tRNA pair that enable its incorporation into a target protein.
Azido-PEG8-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively.
Ammonium glycyrrhizinate is a triterpenoid saponin, acting as a direct HMGB1 antagonist, with anti-inflammatory， anti-tumor, anti-diabetic activities[1][2][3].
BT173 is a small molecule allosteric inhibitor of HIPK2-Smad3 interaction, specifically inhibits the TGF-β1/Smad3 pathway.BT173 disrupts HIPK2-Smad3 protein-protein interaction (PPI) without significant inhibition of HIPK2 kinase activity or inhibition of p53 activation.BT173 inhibits Smad3 phosphorylation in human kidney cells in vitro.BT173 significantly attenuated renal fibrosis development in the UUO mice, significantly decreased Smad3 phosphorylation and α-SMA expression in the UUO kidneys.Treatment of BT173 ameliorated kidney fibrosis in Tg26 mice.
2-Methoxystypandroneis a naphthoquinonethat can be found inPolygonum cuspidatum. 2-Methoxystypandrone showsantioxidantactivities. 2-Methoxystypandrone improves developmental competence of bovine embryos[1].
(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. (2S,3R)-Voruciclib is an orally active CDK inhibitor[1].
CAP 37 (20-44) is a peptide based on amino acid residues 20 through 44 of CAP37. CAP37, a Cationic antimicrobial protein of 37 kDa, is a multifunctional protein[1].
α,β-Trehalose-d14 is the deuterium labeled α,β-Trehalose[1].
Isotianil is a plant defense inducer that has no direct antimicrobial effect but instead activates typical plant defense responses. Isotianil can be used as a plant protection agent for controlling rice blast[1].
Z-D-tyrosine is a tyrosine derivative[1].
Acid-PEG3-SS-PEG3-acid is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Aurora Kinases-IN-4 (Compound 11c) is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM). Aurora Kinases-IN-4 inhibits cell proliferation in SJSA-1, MDA-MB-231, A54, HeLa cells with IC50s of 4.27, 1.54, 3.08, 6.99 μM. Aurora Kinases-IN-4 can be used for research of triple negative breast cancer (TNBC)[1].
CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM.
Atinumab (6A3-IgG4) is an antibody. Teropavimab can be used for the research of spinal cord injury (SCI)[1].
DSPE-PEG2-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.
Isorhamnetin-3-O-glucoside, a natural compound widely contained in many vegetables and rice, could be metabolized in intestinal microbiota after digestion[1].
Hybridaphniphylline B is a Daphniphyllum alkaloid and iridoid hybrid. Hybridaphniphylline B can be isolated from stems and leaves of Daphniphyllum longacemosum[1].