Benzoylaconine(Isaconitine; Pikraconitin) is an alkaloid in the Chinese traditional medicine Radix Aconiti Lateralis Preparata (Fuzi).
(R,S,R)-ML334 is the inactive isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2].
BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM.
Elarekibep (PRS-060) (AZD1402) is a high affinity, slowly dissociating, long-acting full antagonist of IL-4Ra. Elarekibep can be used for the research of T2 endotype asthma[1].
LKKTETQ, a peptide segment, is the active site within the protein thymosin β4 responsible for actin binding, cell migration and wound healing[1].
Diethylamine-d10 hydrobromide is the deuterium labeled Diethylamine hydrobromide[1].
1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent.
2-Fluorobenzoic acid-d4 is the deuterium labeled 2-Fluorobenzoic acid[1].
Spirostan-3-ol is a useful tool to keep bees away from areas recently treated with toxic insecticides[1].
Orcinol (3,5-Dihydroxytoluene) is an organic compound used as biological dye and indicator for proteomics research.
Letaplimab (IBI-188) is a humanized IgG4 anti-CD47 monoclonal antibody. CD47 is overexpressed on cancer cells, it is a ligand for SIRPα. Letaplimab enhances tumor cell phagocytosis[1].
Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors; binding studies are generally used for the latter receptor.
Benzyl 4-hydroxybenzoate is a prominent material. Benzyl 4-hydroxybenzoate can be used as an excipient, such as bacteriostatic agent, preservative. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
6-(Methylthio)purine-d3-1 is the deuterium labeled 6-(Methylthio)purine[1].
Adrenocorticotropic Hormone (ACTH) (1-39), human is a melanocortin receptor agonist.
4-Fluoro-DL-glutamic acid is a glutamic acid derivative[1].
6''-Acetylhyperin is a natural phenolic compounds that could be found in Nymphaea odorata[1].
Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate;L-Pyroglutamic acid methyl ester) is isolated from P. oleracea and has anti-inflammatory activity[1].
Propan-2-amine-d6 (hydrochloride) is the deuterium labeled H-Lys-OH.2HCl[1].
(tert-Butoxycarbonyl)-L-phenylalanyl-L-alanine is an alanine derivative[1].
Oxychelerythrine is an alkaloid that can be isolated from Zanthoxylum integrifoliolum. Oxychelerythrine exhibits cytotoxicity against P-388 and HT-29 cell lines with ED50s of 3.25 and 5.48 μg/mL, respectively[1].
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclohexylpropanoic acid is an alanine derivative[1].
Trijuganone B (Tetrahydro tanshinone I) can be extracted from from the roots of Salvia miltiorrhiza f. alba. Trijuganone B inhibits the proliferation of leukemia cells[1][2].
Abiraterone metabolite 1 is a 5β-reduced metabolite of abiraterone. Abiraterone, a steroidal drug, inhibits CYP17A1, blocks androgen synthesis and prolongs survival in prostate cancer.
Clomethiazole hydrochloride is a sedative and anticonvulsant. Clomethiazole hydrochloride is neuroprotective and prevents the degeneration of serotonergic nerve terminals induced by 3,4-methylenedioxymethamphetamine (MDMA)[1][2].
N,N-dimethyl-4-(phenyldiazenyl)aniline-d5 is the deuterium labeled N,N-dimethyl-4-(phenyldiazenyl)aniline[1].
Transcainide (R 54718) is an orally active antiarrhythmic agent[1].
Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation[1].
CPI-613 is a lipoic acid analog that inhibits pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts mitochondrial metabolism and shows strong antitumor activity.
4-Feruloylquinic acid may be a potential biomarker for food products[1].