Guar gum is a versatile polymer for drug delivery applications. Guar gum diaplays thickening, emulsifying, binding and gelling properties, quick solubility in cold water, wide pH stability, film forming ability and biodegradability, it finds applications in large number of industries. Guar gum can be isolated from the powdered endosperm of the seeds of the Cyamopsis tetragonolobus. Guar gum can be used as an excipient, such as thickener, suspending agent. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2][3].
N6-Ethyladenosine is an adenosine derivative, acts as a Adenosine receptor agonist, with Kis of 4.9 and 4.7 nM for hA1AR and hA3AR, respectively[1].
Z-D-Glu-OH is a glutamic acid derivative[1].
Calcitonin, eel is the thyroid hormone peptide that contributes to the regulation of calcium homeostasis, widely used in the research of postmenopausal osteoporosis.
Ginkgolide B, an important active terpenoid from Ginkgo biloba leaves, is reported to increase cell viability and decrease cell apoptosis.IC50 value:Target:In vitro: Ginkgolide B (0.2 or 0.4 μg/ml) was added to the culture medium in vitro led to increases in cell viability and decreases in the number of hippocampal cells undergoing AAPH-induced apoptosis [1]. Ginkgolide B caused a dose-related protection against dysrhythmias; the antiarrhythmic effect of ginkgolide B was comparable to that of diltiazem and superior to the activity of metoprolol. Ginkgolide B can presumably prevent the re-entry mechanism involved in the development of ischemia-induced rhythm disturbances [2].In vivo: Oral administration of ginkgolide B (2 mg/kg/day, p.o.) caused a significant increase in cell viability and a highly significant decrease in the numbers of both spontaneously occurring and AAPH-induced apoptoses.
MTOA-TFSI is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
(R)-Boc-3-methoxy-β-Phe-OH is a phenylalanine derivative[1].
Tris Dodecyl Sulfate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
H-Glu(OtBu)-OMe.HCl is a glutamic acid derivative[1].
(S)-2-Amino-3-(3-chlorophenyl)propanoic acid hydrochloride is a phenylalanine derivative[1].
2,4-D-d3 is the deuterium labeled 2,4-D[1]. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[2].
Arundinin is a stilbenoid from Bletilla striata[1].
N-Acetyl-DL-valine is a valine derivative[1].
Cholebrine (DRC 1201), a diagnostic aid, is an orally active chotecystographic contrast agent[1].
SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)
2-(2'-Hydroxy-4'-methylphenyl)propionic acid is an active compound[1].
DL-Thyronine protects trypsin from photodynamic inactivation sensitized by Riboflavin-5'-phosphate (FMN)[1].
18:0 PEG-PE is a polyethyleneglycol/phosphatidyl-ethanolamine conjugate. 18:0 PEG-PE can be used for drug delivery[1].
2-(Bis(2-(tert-butoxy)-2-oxoethyl)amino)acetic acid is a Glycine (HY-Y0966) derivative[1].
Calcitonin (rat) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1].
Calpastatin subdomain B is a biological active peptide. (inhibit calpain activity)
Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties. IC50 value:Target:In vitro: Experimental set examined the influence of palmatine on osteoblast-like cells in vitro. In the culture supernatant of MC3T3-E1 cells, RANKL and OPG levels were significantly reduced by palmatine addition [1]. In vivo: The first experimentaI set was designed to histologically and biochemically examine mice randomly divided into four groups: sham-operated, OVX, and OVX-palmatine intake groups (1 mg/kg and 10 mg/kg). In palmatine-treated mice, RANKL and OPG expression decreased [1].
Bemotrizinol (Tinosorb S), an ultraviolet (UV) filter, has been shown to accept atomic oxygen generated by N-oxide photodeoxygenation[1].
Myricanol is a constituent of Myrica cerifera (bayberry/southern wax myrtle) root bark. Myricanol can lower the levels of the microtubule-associated protein tau (MAPT)[1].
Oxonol V is a slow-response sensitive probe for measuring cellular membrane potential.
Boc-Lys(Z)-OSu is a lysine derivative[1].
Coelenteramide is a oxidative product of Coelenterazine (HY-18743). Coelenteramide can form a complex with apoAequorin/Ca2+, which is known as blue fluorescent protein (BFP) and shows continuous weak luminescence with Coelenterazine like a luciferase. Coelenteramide can be used as an imaging agent[1].
Ganoderic acid Me is a triterpenoid that can be found in ganoderma lucidum[1].
Chol-N3 is a bioorthogonal-based chol probe. Chol-N3 can combine with super-resolution fluorescence microscopy (SRM), providing direct visualization of nanoscale lipid heterogeneity in the cell surface of resting living cells[1].
AF647-NHS ester is an analogue of Alexa Fluor 647 (AF647)[1].