t-Boc-Aminooxy-PEG7-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
CH2COOH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
BCN-exo-PEG3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein[1].
m-PEG8-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Butane-1,4-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia[1][2][3].
Boc-PEG2-ethoxyethane-PEG2-benzyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
(S,R,S)-AHPC-C7-amine (VH032-C7-amine) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader[1].
N-Mal-N-bis(PEG4-amine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ARV-771 is a potent bromodomain and extra-terminal (BET) proteins degrader based on PROTAC technology with Kd values of 4.7, 7.6, 7.6 nM against BRD2, BRD3 and BRD4, respectively.
Azido-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Mal-amido-PEG2-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biotin-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ARD-69 (compound 34) is a potent PROTAC androgen receptor degrader. ARD-69 induces degradation of androgen receptor (AR) protein in AR-positive prostate cancer cell lines. ARD-69 suppresses AR-regulated gene expression[1].
Oleic-DBCO is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-(m-PEG4)-N'-(amino-PEG3)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Benzyl-PEG2-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
m-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Triethylene glycol monobenzyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Mal-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Bromo-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
m-PEG16-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Acid-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Amino-PEG2-(CH2)3COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Ethyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]
TL12-186 is a CRBN-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM)[1].