PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
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UV Cleavable Biotin-PEG2-Azide

UV Cleavable Biotin-PEG2-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1192802-98-4
  • MF: C38H51N7O9S
  • MW: 781.92
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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NH2-PEG2-C6-Cl

NH2-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 744203-60-9
  • MF: C10H22ClNO2
  • MW: 223.74
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG3-Sulfone-PEG4-Boc

Azido-PEG3-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055023-76-0
  • MF: C23H45N3O11S
  • MW: 571.68
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Tos-PEG2-THP

Tos-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 69502-32-5
  • MF: C16H24O6S
  • MW: 344.42
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG7-thiol

m-PEG7-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 651042-82-9
  • MF: C15H32O7S
  • MW: 356.47500
  • Catalog: PROTAC Linker
  • Density: 1.065
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-NH-PEG2-NH-Boc

Boc-NH-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 475591-59-4
  • MF: C16H32N2O6
  • MW: 348.43500
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Cbz-NH-PEG8-C2-acid

Cbz-NH-PEG8-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1334177-87-5
  • MF: C27H45NO12
  • MW: 575.646
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 681.2±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 365.8±31.5 °C
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Bis-propargyl-PEG1

Bis-propargyl-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 40842-04-4
  • MF: C8H10O2
  • MW: 138.16400
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Boc-Aminooxy-PEG2-amine

Boc-Aminooxy-PEG2-C2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 252378-69-1
  • MF: C11H24N2O5
  • MW: 264.32
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG2-O-Ph-NH2

m-PEG2-O-Ph-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 65673-48-5
  • MF: C11H17NO3
  • MW: 211.25800
  • Catalog: PROTAC Linker
  • Density: 1.086g/cm3
  • Boiling Point: 346.2ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 173.9ºC
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Cl-PEG2-acid

Cl-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 170304-76-4
  • MF: C6H11ClO4
  • MW: 182.60
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Diethylene Glycol Monobenzyl Ether

Diethylene Glycol Monobenzyl Ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2050-25-1
  • MF: C11H16O3
  • MW: 196.243
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 311.2±22.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 142.0±22.3 °C
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CH2COOH-PEG6-CH2COOH

CH2COOH-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 83824-29-7
  • MF: C16H30O11
  • MW: 398.40300
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(Azido-PEG4)-biocytin

N-(Azido-PEG4)-biocytin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055042-70-9
  • MF: C27H47N7O9S
  • MW: 645.77
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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NH2-PEG3-C2-Boc

NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 252881-74-6
  • MF: C13H27NO5
  • MW: 277.35700
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: 169.7ºC
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Azido-PEG6-acid

Azido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 361189-66-4
  • MF: C15H29N3O8
  • MW: 379.41
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Ms-PEG2-C2-Boc

Ms-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1312309-62-8
  • MF: C12H24O7S
  • MW: 312.380
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 429.2±30.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 213.4±24.6 °C
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N-(t-butyl ester-PEG3)-N-bis(PEG3-azide)

N-(Boc-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2182602-15-7
  • MF: C29H57N7O11
  • MW: 679.80
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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DBCO-PEG4-NH-Boc

DBCO-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353410-17-8
  • MF: C34H45N3O8
  • MW: 623.74
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG3-S-PEG4-propargyl

m-PEG3-S-PEG4-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055040-85-0
  • MF: C18H34O7S
  • MW: 394.52
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG35-amine

Azido-PEG35-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2301851-71-6
  • MF: C72H146N4O35
  • MW: 1627.95
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Amino-PEG7-acid

Amino-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2376111-92-9
  • MF: C17H35NO9
  • MW: 397.46
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bis-PEG9-acid

Bis-​PEG9-​acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-​PEG9-​acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

  • CAS Number: 1268488-70-5
  • MF: C22H42O13
  • MW: 514.561
  • Catalog: ADC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 630.0±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 201.6±25.0 °C
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Bromoacetamido-PEG2-C2-acid

Bromoacetamido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1415800-44-0
  • MF: C9H16BrNO5
  • MW: 298.131
  • Catalog: PROTAC Linker
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 491.4±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 251.0±28.7 °C
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Azido-PEG3-amide-C3-triethoxysilane

Azido-PEG3-amide-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2243566-43-8
  • MF: C18H38N4O7Si
  • MW: 450.60
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG4-alcohol

Propargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 87450-10-0
  • MF: C11H20O5
  • MW: 232.27300
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Sulfo DBCO-PEG4-Maleimide

Sulfo DBCO-PEG4-Maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055198-07-5
  • MF: C39H47N5O13S
  • MW: 825.88
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG3-Sulfone-PEG4-propargyl

m-PEG3-Sulfone-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055041-02-4
  • MF: C18H34O9S
  • MW: 426.52
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Ms-PEG4-t-butyl ester

Ms-PEG4-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 870487-48-2
  • MF: C16H32O9S
  • MW: 400.485
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 499.9±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 256.1±27.3 °C
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Bis-propargyl-PEG4

Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers[1][2].

  • CAS Number: 159428-42-9
  • MF: C14H22O5
  • MW: 270.322
  • Catalog: PROTAC Linker
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 338.7±37.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 130.7±26.4 °C
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