PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
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Mal-PEG4-acid

Mal-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 518044-41-2
  • MF: C15H23NO8
  • MW: 345.34500
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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PEG3-bis(phosphonic acid diethyl ester)

PEG3-bis(phosphonic acid diethyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1807539-03-2
  • MF: C14H32O10P2
  • MW: 422.35
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG2-C1-Boc

Azido-PEG2-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 251564-45-1
  • MF: C10H19N3O4
  • MW: 245.27600
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Cl-C6-PEG4-C3-COOH

Cl-C6-PEG4-C3-COOH is a PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs)[1].

  • CAS Number: 2127391-58-4
  • MF: C18H35ClO6
  • MW: 382.92
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(Acid-PEG2)-N-bis(PEG2-propargyl)

N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2100306-49-6
  • MF: C21H35NO8
  • MW: 429.50
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Ms-PEG6-THP

Ms-PEG6-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 42607-89-6
  • MF: C18H36O10S
  • MW: 444.54
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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S-acetyl-PEG3-Boc

S-acetyl-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1818294-27-7
  • MF: C15H28O6S
  • MW: 336.444
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 413.9±35.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 188.4±14.0 °C
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Tetraethyl octane-1,8-diylbis(phosphonate)

Tetraethyl octane-1,8-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 5943-61-3
  • MF: C16H36O6P2
  • MW: 386.40100
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol

PROTAC Linker 18 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 18 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

  • CAS Number: 112-60-7
  • MF: C8H18O5
  • MW: 194.225
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 328.0±0.0 °C at 760 mmHg
  • Melting Point: -5.6 °C(lit.)
  • Flash Point: 176.7±0.0 °C
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Bis-(m-PEG4)-amidohexanoic acid

Bis-(m-PEG4)-amidohexanoic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353409-74-0
  • MF: C26H50N2O12
  • MW: 582.68
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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endo-BCN-PEG4-Boc

endo-BCN-PEG4-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 1807501-83-2
  • MF: C26H43NO8
  • MW: 497.621
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 594.3±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 313.2±28.7 °C
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17-ODYA

Alkynyl Stearic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 34450-18-5
  • MF: C18H32O2
  • MW: 280.445
  • Catalog: PROTAC Linker
  • Density: 0.9±0.1 g/cm3
  • Boiling Point: 400.8±18.0 °C at 760 mmHg
  • Melting Point: 142-148 °C(lit.)
  • Flash Point: 194.7±15.9 °C
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endo-BCN-PEG8-acid

endo-BCN-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2126805-02-3
  • MF: C30H51NO12
  • MW: 617.73
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-peg2-t-butyl ester

Mal-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1374666-31-5
  • MF: C15H23NO6
  • MW: 313.35
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-N-Amido-PEG2-C2-azide

Boc-N-Amido-PEG2-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 950683-55-3
  • MF: C11H22N4O4
  • MW: 274.31700
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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S-acetyl-PEG5-alcohol

S-acetyl-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1000415-61-1
  • MF: C12H24O6S
  • MW: 296.38
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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1,14-Diazido-3,6,9,12-tetraoxatetradecane

Azido-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 182760-73-2
  • MF: C10H20N6O4
  • MW: 288.30400
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Hydroxy-PEG3-ethyl acetate

Hydroxy-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 118988-04-8
  • MF: C10H20O6
  • MW: 236.26200
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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NH2-C2-NH-Boc-d4

NH2-C2-NH-Boc-d4 is the deuterium labeled NH2-C2-NH-Boc[1]. NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs[2].

  • CAS Number: 509148-73-6
  • MF: C7H12D4N2O2
  • MW: 164.239
  • Catalog: PROTAC Linker
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 252.8±23.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 106.7±22.6 °C
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1,1,1-Trifluoroethyl-PEG2-azide

1,1,1-Trifluoroethyl-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1835759-68-6
  • MF: C6H10F3N3O2
  • MW: 213.16
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Acid-PEG5-mono-methyl ester

Acid-PEG5-mono-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1309460-30-7
  • MF: C15H28O9
  • MW: 352.377
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 469.4±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 161.3±22.2 °C
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N-Methyl-N'-(hydroxy-PEG2)-Cy5

N-Methyl-N'-(hydroxy-PEG2)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2107273-22-1
  • MF: C32H41ClN2O3
  • MW: 537.13
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azide-PEG12-Tos

Azide-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1821464-56-5
  • MF: C31H55N3O14S
  • MW: 725.85
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG3-alcohol

Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 86520-52-7
  • MF: C6H13N3O3
  • MW: 175.18600
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: -33℃
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