5-Biotinamidopentylazide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Propargyl-PEG12-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
YX-2-107 is a CRBN-recruiting and specific CDK6-degrading PROTAC with IC50 of 0.69 and 4.4 nM for CDK4 and CDK6 in vitro, selectively degardes CDK6 in Ph+ BV173 ALL cells with a degradation constant of 4 nM.YX-2-107 does not affect expression of IKZF1 and IKZF3, and does not degarde CDK4 protein.YX-2-107 inhibits S-phase entry, cell proliferation, RB phosphorylation, and FOXM1 expression and induces the selective degradation of CDK6 in Ph+ BV173 and SUP-B15 cells.|PROTAC YX-2-107 is bioavailable in mice and pharmacologically active in suppressing Ph+ ALL proliferation in a mouse xenograft of Ph+ ALL, comparable or superior to that of the CDK4/6 enzymatic inhibitor palbociclib.
Azido-PEG20-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
N-Boc-C1-PEG5-C3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Sulfo DBCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
m-PEG8-C10-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
dBET6 is a highly potent, selective and cell-permeable degrader of BET based on PROTAC, with an IC50 of 14 nM, and has antitumor activity.
Bromoacetamide-PEG3-C1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Bis-aminooxy-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
HS-PEG7-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
(S,R,S)-AHPC-C1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology[1].
N,N-Diethanol amine-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
m-PEG4-C6-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Fmoc-Val-Phe-Boc is a PROTAC linker and a maleimide-GGFG peptide linker. Fmoc-Val-Phe-Boc can be used in the synthesis of the Deruxtecan[1].
Bis-Mal-Lysine-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
DBCO-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Pomalidomide-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTAC MEK1 Degrader-1 is a PROTAC targeting MEK1 with a pIC50 value of 7.0. PROTAC MEK1 Degrader-1 consists of a MEK1 inhibitor and a von Hippel-Lindau ligand. PROTAC MEK1 Degrader-1 can inhibit ERK1/2 phosphorylation. PROTAC MEK1 Degrader-1 shows an antiproliferative activity against A375 cells[1].
Tos-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-Boc-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Alkynyl Palmitic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Aminooxy-PEG4-alcohol is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG4-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
N-(Mal-PEG6)-N-bis(PEG3-amine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide-NH-PEG7 is a synthesized E3 ligase ligand-linker conjugate for ADC. Thalidomide-NH-PEG7 can be connected to the ligand for protein by a linker to form PROTAC iRucaparib-AP6, a highly specific PARP1 degrader[1].
Thalidomide-5-PEG2-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-PEG2-Cl can be connected to the ligand for protein by a linker to form PROTACs[1].
Ald-CH2-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].