PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
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Vitamin D Related >
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Acids and Aldehydes

Fmoc-NH-PEG1-C2-acid

Fmoc-NH-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1654740-73-4
  • MF: C20H21NO5
  • MW: 355.384
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 589.9±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 310.6±27.3 °C
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m-PEG7-CH2-OH

m-PEG7-CH2-OH a PEG-based based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 1807512-35-1
  • MF: C16H34O8
  • MW: 354.436
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 436.2±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 217.6±27.3 °C
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Tetraethyl decane-1,10-diylbis(phosphonate)

Tetraethyl decane-1,10-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 5943-62-4
  • MF: C18H40O6P2
  • MW: 414.45400
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bis-(m-PEG8-amido)-hexanoic acid

Bis-(m-PEG8-amido)-hexanoic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353409-77-3
  • MF: C42H82N2O22
  • MW: 967.10
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Sulfo-NHS-Acetate sodium

Sulfo-NHS-Acetate sodium is an alkyl chain-based PROTAC linker. Sulfo-NHS-Acetate sodium can be used in the synthesis of PROTACs[1].

  • CAS Number: 221222-61-3
  • MF: C6H6NNaO7S
  • MW: 259.17
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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endo-BCN-PEG3-acid

endo-BCN-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-C16-COOH

Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]

  • CAS Number: 843666-40-0
  • MF: C22H42O4
  • MW: 370.56600
  • Catalog: ADC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG5-CH2CO2-PFP

Azido-PEG5-CH2CO2-PFP is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 2144777-92-2
  • MF: C18H22F5N3O7
  • MW: 487.38
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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[4-(Diethoxy-phosphorylamino)-butyl]-phosphoramidic acid diethyl ester

Tetraethyl butane-​1,​4-​diylbis(phosphoramid​ate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 720707-93-7
  • MF: C12H30N2O6P2
  • MW: 360.32
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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CBZ-NH-PEG4-CH2CH2COOH

Cbz-NH-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 756526-00-8
  • MF: C19H29NO8
  • MW: 399.43546
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyl-PEG1-Tos

Benzyl-PEG1-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 4981-83-3
  • MF: C16H18O4S
  • MW: 306.37700
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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NH2-PEG2-methyl acetate

NH2-PEG2-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 741235-80-3
  • MF: C7H15NO4
  • MW: 177.20
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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NH-(PEG4-acid)2

NH-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055041-59-1
  • MF: C22H43NO12
  • MW: 513.58
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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THP-PEG1-alcohol

THP-PEG1-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2162-31-4
  • MF: C7H14O3
  • MW: 146.184
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 255.3±30.0 °C at 760 mmHg
  • Melting Point: 95ºC 22 mm Hg(lit.)
  • Flash Point: 108.2±24.6 °C
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t-boc-N-amido-PEG5-azide

Boc-NH-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 911209-07-9
  • MF: C17H34N4O7
  • MW: 406.47
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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2-Amino-1,3-bis(carboxylethoxy)propane HCl

2-Amino-13-bis(carboxylethoxy)propane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1020112-73-5
  • MF: C9H17NO6
  • MW: 235.23
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG8-ethoxycarbonyl--NHS ester

m-PEG8-ethoxycarbonyl--NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353409-76-2
  • MF: C25H43NO14
  • MW: 581.61
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG1-NHS ester

m-PEG1-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 1027371-75-0
  • MF: C8H11NO5
  • MW: 201.18
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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NH-bis(PEG4-Boc)

NH-bis(PEG4-C2-NH-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2182601-75-6
  • MF: C30H61N3O12
  • MW: 655.82
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-PEG1-Boc

Boc-PEG1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 727729-33-1
  • MF: C14H26O6
  • MW: 290.35
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Tetra(cyanoethoxymethyl) methane

Tetra(cyanoethoxymethyl) methane is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2465-91-0
  • MF: C17H24N4O4
  • MW: 348.39700
  • Catalog: PROTAC Linker
  • Density: 1.13g/cm3
  • Boiling Point: 610.6ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 232ºC
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Biotin-PEG6-acid

Biotin-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

  • CAS Number: 1352814-10-8
  • MF: C25H45N3O10S
  • MW: 579.704
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 818.4±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 448.8±34.3 °C
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Desthiobiotin-PEG4-DBCO

DBCO-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2032788-37-5
  • MF: C39H53N5O8
  • MW: 719.87
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-boc-N-amido-PEG7-azide

Boc-NH-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 206265-96-5
  • MF: C21H42N4O9
  • MW: 494.58
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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heptaethylene glycol

Heptaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 5617-32-3
  • MF: C14H30O8
  • MW: 326.383
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 435.0±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 216.9±27.3 °C
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m-PEG6-amino-Mal

m-PEG6-amino-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1644231-07-1
  • MF: C20H34N2O9
  • MW: 446.492
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 604.5±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 319.4±31.5 °C
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Acid-PEG3-SSPy

Acid-PEG3-SSPy is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2088570-69-6
  • MF: C14H21NO5S2
  • MW: 347.45
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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S-acetyl-PEG6-Boc

S-acetyl-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1818294-39-1
  • MF: C21H40O9S
  • MW: 468.602
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 522.5±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 242.0±18.1 °C
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Vipivotide tetraxetan Linker

Vipivotide tetraxetan Linker is a useful peptide linker for synthesis of Vipivotide tetraxetan (PSMA-617). Vipivotide tetraxetan (PSMA-617) is a ligand used to synthesize 177Lu-PSMA-617, which is a radioactive molecule for the treatment of prostate cancer[1].

  • CAS Number: 1703768-74-4
  • MF: C33H45N5O9
  • MW: 655.74
  • Catalog: ADC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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SMPH Crosslinker

SMPH Crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 367927-39-7
  • MF: C17H21N3O7
  • MW: 379.36500
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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