Pomalidomide-C3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
m-PEG16-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer[1].
Boc-NH-PEG5-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Tos-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biotin-PEG2-C4-alkyne is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Fmoc-N-amido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-(Amino-PEG4)-N-Biotin-PEG4-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Acid-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Mal-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Cl-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
(+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Bromo-PEG3-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2)[1].
Boc-NH-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
m-PEG7-4-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<
(S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader[1].
Protein degrader 1 TFA is a small molecule ligand for VHL, an E3 ligase which has been targeted in numerous PROTACs.
m-PEG3-Sulfone-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
CD147 degrader 1 is a PROTAC targets CD147 with an DC50 value of 6.72 µM. CD147 degrader 1 inhibits cell proliferation, migration and invasion. CD147 degrader 1 decreases the expression of CD147, MMP9, and p-STAT3 protein. CD147 degrader 1 shows anti-cancer acyivity[1].
Benzyl-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Azido-PEG3-C-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Methylamino-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTAC Linker 4 is a PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).