Sulfone-Bis-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
S-acetyl-PEG4-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biotin-Thalidomide is a cereblon affinity probe for PROTAC and targeted protein degradation research.
Benzyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
m-PEG4-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
S-Acetyl-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N,N'-DME-N-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
3,4-Dibromo-Mal-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Bromo-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTAC Linker 24 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 24 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Thalidomide-5-CH2-NH2 (hydrochloride) is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-CH2-NH2 (hydrochloride) can be connected to the ligand for protein by a linker to form PROTACs[1].
HO-PEG8-CH2CH2COOH (Hydroxy-PEG8-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Aminooxy-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
NH2-C6-NH-Boc is a PROTAC linker which refers to the alkyl/ether composition. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC[1].
FmocNH-PEG4-t-butyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide-Piperazine-PEG2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
m-PEG4-CH2-methyl ester is a PEG- and Alkyl/ester-based PROTAC linker can be used in the synthesis of PROTACs[1].
β-Estradiol-6-one 6-(O-carboxymethyloxime) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Amino-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Dovitinib RIBOTAC TFA is a targeted RNA degrader that cleaves pre-miR-21 with enhanced potency and selectivity.
Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
m-PEG3-succinimidyl carbonate is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Br-Boc-C2-azido is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-(Azido-PEG4)-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder[1].
PEG3-bis-(ethyl phosphonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
SPDP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Boc-NH-PEG7-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
S-Acetyl-PEG3-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].