PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
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Vitamin D Related >
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TCO-PEG3-triethoxysilane

TCO-PEG3-amide-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2250217-32-2
  • MF: C27H52N2O9Si
  • MW: 576.80
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Ethyl acetate-PEG1

Ethyl acetate-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2093-20-1
  • MF: C6H12O4
  • MW: 148.15700
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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HO-PEG14-OH

HO-PEG14-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1189112-05-7
  • MF: C28H58O15
  • MW: 634.751
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 660.2±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 353.1±30.1 °C
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HO-PEG18-OH

HO-PEG18-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 4445-03-8
  • MF: C36H74O19
  • MW: 810.96
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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HS-PEG8-CH2CH2COOH

Thiol-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 866889-02-3
  • MF: C19H38O10S
  • MW: 458.56400
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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THP-CH3-ethyl propionate

THP-CH3-ethyl propionate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 3539-40-0
  • MF: C10H18O4
  • MW: 202.24800
  • Catalog: PROTAC Linker
  • Density: 1.05g/cm3
  • Boiling Point: 292.7ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 125.6ºC
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Biotin-PEG6-Thalidomide

Biotin-PEG6-Thalidomide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2144775-48-2
  • MF: C37H53N5O12S
  • MW: 791.91
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(m-PEG4)-N'-(biotin-PEG3)-Cy5

N-(m-PEG4)-N'-(biotin-PEG3)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2107273-68-5
  • MF: C52H76ClN5O9S
  • MW: 982.71
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Ac4GlcNAlk

Ac4GlcNAlk is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1361993-37-4
  • MF: C19H25NO10
  • MW: 427.40
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Methylamino-PEG3-acid

Methylamino-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2148295-95-6
  • MF: C10H21NO5
  • MW: 235.28
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bis-Mal-Lysine-PEG4-TFP ester

Bis-Mal-Lysine-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1426164-53-5
  • MF: C37H45F4N5O13
  • MW: 843.773
  • Catalog: PROTAC Linker
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 1012.1±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 565.9±34.3 °C
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Acryloyl-PEG4-OH

Acryloyl-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 26150-06-1
  • MF: C11H22O5
  • MW: 234.28900
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG11-OH

m-PEG11-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 2168540-65-4
  • MF: C23H48O12
  • MW: 516.62
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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SPDP-C6-NHS ester

SPDP-C6-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 158913-22-5
  • MF: C18H23N3O5S2
  • MW: 425.52200
  • Catalog: PROTAC Linker
  • Density: 1.36g/cm3
  • Boiling Point: N/A
  • Melting Point: 82-84ºC
  • Flash Point: N/A
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Biotin-PEG2-NHS ester

Biotin-PEG2-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 596820-83-6
  • MF: C21H32N4O8S
  • MW: 500.56578
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Pyrene-PEG2-azide

Pyrene-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2135330-58-2
  • MF: C23H22N4O3
  • MW: 402.45
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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BM-PEG3

BM-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 86099-06-1
  • MF: C16H20N2O7
  • MW: 352.33900
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 71-72ºC
  • Flash Point: N/A
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Folate-PEG3-alkyne

Folate-PEG3-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1245285-73-7
  • MF: C28H34N8O8
  • MW: 610.62
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Hydroxy-Amino-bis(PEG1-C2-Boc)

Hydroxy-Amino-bis(PEG1-C2-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1415800-34-8
  • MF: C20H39NO7
  • MW: 405.526
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 478.7±35.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 243.3±25.9 °C
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Bocnh-peg12-ch2ch2nh2

Boc-NH-PEG12-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1642551-09-4
  • MF: C31H64N2O14
  • MW: 688.84
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(NHS-PEG3)-N-bis(PEG3-azide)

N-(NHS-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2182602-16-8
  • MF: C29H52N8O13
  • MW: 720.77
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bis-PEG1-acid

Bis-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 5961-83-1
  • MF: C6H10O5
  • MW: 162.14100
  • Catalog: PROTAC Linker
  • Density: 1.316g/cm3
  • Boiling Point: 371.4ºC at 760 mmHg
  • Melting Point: 60-61°C(lit.)
  • Flash Point: 158.7ºC
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Trityl-PEG8-azide

Trityl-PEG8-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1818294-30-2
  • MF: C35H47N3O8
  • MW: 637.763
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(Propargyl-PEG4)-biocytin

N-(Propargyl-PEG4)-biocytin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055042-71-0
  • MF: C28H46N4O9S
  • MW: 614.75
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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TAMRA-PEG3-biotin

TAMRA-PEG3-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2279944-59-9
  • MF: C43H54N6O9S
  • MW: 830.99
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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1,7-Bis-Boc-1,4,7-triazaheptane

1,7-Bis-Boc-1,4,7-triazaheptane is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 117499-16-8
  • MF: C14H29N3O4
  • MW: 303.39800
  • Catalog: PROTAC Linker
  • Density: 1.0±0.1g/cm3
  • Boiling Point: 440.5±30.0°C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 220.2±24.6°C
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N3-PEG3-CH2CH2-Boc

N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2].

  • CAS Number: 252881-73-5
  • MF: C13H25N3O5
  • MW: 303.35500
  • Catalog: ADC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-PEG1-Bromide

Mal-PEG1-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1823885-81-9
  • MF: C8H10BrNO3
  • MW: 248.07
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-PEG3-Boc

Mal-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 518044-35-4
  • MF: C17H27NO7
  • MW: 313.346
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 428.7±30.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 213.1±24.6 °C
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Bromoacetamido-PEG8-t-butyl ester

Bromoacetamido-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055041-16-0
  • MF: C25H48BrNO11
  • MW: 618.55
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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